Facile synthesis of trifluoromethyl carbinols and trifluoromethyl- α,β-unsaturated ketones from the new CF3CHO synthetic equivalent, 1,1- bis(dimethylamino)-2,2,2-trifluoroethane
1,1-Bis(dimethylamino)-2,2,2-trifluoroethane is an excellent synthetic building-block replacement for trifluoroacetaldehyde in condensation reactions with ketones using 36% aqueous HCl catalysis. Moderate to good yields (43-68%) of trifluoromethyl carbino
Xu, Yuelian,Dolbier Jr., William R.
p. 9151 - 9154
(2007/10/03)
Facile Synthesis of α-Trifluoromethylated Alcohols from Trifluoroacetaldehyde Ethyl Hemiacetal
Trifluoroacetaldehyde ethyl hemiacetal reacted with nucleophilic organosilanes such as cyanotrimethylsilane, allyltrimethylsilane, or enol trimethylsilyl ethers in the presence of Lewis acid to afford a series of α-trifluoromethylated alcohols in high yield. Key Words: trifluoroacetaldehyde ethyl hemiacetal; Lewis acid; trimethylsilylated nucleophiles; carbon-carbon bond formation; α-trifluoromethylated alcohol.
Kubota, Toshio,Iijima, Masahiro,Tanaka, Tatsuo
p. 1351 - 1354
(2007/10/02)
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