141042-21-9

Basic information

• Product Name: cis-2-fluorocyclopropylaminetosylate
• Synonyms: (1R,2S)-fluorocyclopropylamine hydrochloride
• CAS NO: 141042-21-9
• Molecular Formula: C₃H₆FN*ClH
• Molecular Weight: 0
• Mol File: 141042-21-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: cis-2-fluorocyclopropylaminetosylate(CAS DataBase Reference)
• NIST Chemistry Reference: cis-2-fluorocyclopropylaminetosylate(141042-21-9)
• EPA Substance Registry System: cis-2-fluorocyclopropylaminetosylate(141042-21-9)

Safety Data

• Hazardous Substances Data: 141042-21-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
Cis-2-fluorocyclopropylaminetosylate is used as a key intermediate in the synthesis of pharmaceuticals for its ability to influence the properties and reactivity of the target molecules. The fluorine and cyclopropyl groups contribute to the compound's unique characteristics, which are often desirable in drug development.
Used in Organic Chemistry Research:
In the field of organic chemistry, cis-2-fluorocyclopropylaminetosylate is employed as a versatile building block for the development of new organic compounds. Its tosylate functional group provides a convenient handle for further chemical modifications, facilitating the exploration of novel synthetic pathways and the creation of diverse chemical libraries.
Used in Medicinal Chemistry:
Cis-2-fluorocyclopropylaminetosylate is utilized as a structural component in the design of new medicinal agents. The presence of the fluorine atom and the cyclopropyl group can significantly affect the pharmacokinetics and pharmacodynamics of the resulting compounds, potentially leading to improved therapeutic efficacy and selectivity.
Used in Chemical Synthesis Education:
cis-2-fluorocyclopropylaminetosylate serves as an instructive example in educational settings for teaching the principles of organic synthesis, the use of protecting groups, and the influence of functional groups on molecular properties. Its structure and reactivity provide a practical case study for students learning about synthetic strategies and chemical transformations.

Upstream product

• 142977-41-1 benzyl N-diphenylmethyl-N-<(1R*,2S*)-2-fluorocyclopropyl>carbamate 
• 142977-42-2 t-butyl N-diphenylmethyl-N-<(1R*,2S*)-2-fluorocyclopropyl>carbamate 
• 142977-39-7 benzyl N-<(1R*,2S*)-2-fluorocyclopropyl>-N-(1-phenylethyl)carbamate 
• 142977-40-0 t-butyl N-<(1R*,2S*)-2-fluorocyclopropyl>-N-(1-phenylethyl)carbamate 
• 142977-37-5 benzyl N-benzyl-N-<(1R*,2S*)-2-fluorocyclopropyl>carbamate 
• 142977-38-6 t-butyl N-benzyl-N-<(1R*,2S*)-2-fluorocyclopropyl>carbamate 
• 142977-37-5 benzyl N-benzyl-N-<(1R*,2R*)-2-fluorocyclopropyl>carbamate 
• 143062-73-1 (1R*,2S*)-2-fluorocyclopropylammonium p-toluenesulfonate 
• 142977-51-3 (4R,5S)-3-((1R,2S)-2-Fluoro-cyclopropyl)-4,5-diphenyl-oxazolidin-2-one 
• 114152-95-3 (1R*,2S*)-2-fluorocyclopropylamine hydrochloride 
• 142977-48-8 (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl N-(1R,2S)-2-fluorocyclopropylcarbamate 

Downstream Products

• 142977-48-8 (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl N-(1R,2S)-2-fluorocyclopropylcarbamate 
• 143059-80-7 (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl N-(1S,2R)-2-fluorocyclopropylcarbamate 
• 105919-35-5 tert-butyl dl-N-(cis-2-fluorocyclopropyl)carbamate 
• 105919-35-5 tert-butyl dl-N-(trans-2-fluorocyclopropyl)carbamate 
• 142977-49-9 N-((1R,2S)-2-Fluoro-cyclopropyl)-3,5-dinitro-benzamide 
• 127199-16-0 tert-butyl N-<(1R,2S)-2-fluorocyclopropyl>carbamate 

Relevant articles and documents

Synthetic studies on the key component of the new generation of quinolonecarboxylic acid, DU-6859. 1. Synthesis of (1R,2S)-2-fluorocyclopropylamine by the use of optical resolution

The title synthesis was achieved by employing highly cis-selective cyclopropanation of N-benzyl-N-vinylcarbamates with zinc-monofluorocarbenoid, deprotection of the formed N-benzyl-N-(cis-2-fluorocyclopropyl)carbamates, and optical resolution of the resul

Synthetic Studies on the Key Component of the New Generation of Quinolonecarboxylic Acid, DU-6859. 2. Asymmetric Synthesis of (1R,2S)-2-Fluorocyclopropylamine

The title synthesis was achieved by featuring diastereoface-selective cyclopropanation of (4R,5S)-4,5-diphenyl-3-vinyl-2-oxazolidinone and its related compounds, the chiral conformationally rigid N-vinylcarbamates, with zinc-monofluorocarbenoid, followed

Synthesis and optical resolution of dl-cis-2-fluorocyclopropylamine, the key component of the new generation of quinolonecarboxylic acid, DU-6859

The title synthesis was accomplished by featuring highly cis-selective cyclopropanation of an N-vinylcarbamate with zinc-monofluorocarbenoid followed by deprotection of the formed N-(cis-2-fluorocyclopropyl)carbamate. Optical resolution of dl-cis-2-fluoro

Asymmetric Synthesis of (1R,2S)-2-Fluorocyclopropylamine, the Key Intermediate of the New Generation of Quinolonecarboxylic Acid, DU-6859

The title synthesis was achieved by featuring diastereoface selective cyclopropanation of (4R,5S)-4,5-diphenyl-3-vinyl-2-oxazolidinone, the chiral and conformationally rigid N-vinylcarbamate, with zincmonofluorocarbenoid followed by hydrogenolysis of form