1410633-49-6

Basic information

• Product Name: C₁₂H₁₄N₂O₃
• Synonyms: C₁₂H₁₄N₂O₃
• CAS NO: 1410633-49-6
• Molecular Weight: 234.255
• Mol File: 1410633-49-6.mol

Chemical Properties

• CAS DataBase Reference: C₁₂H₁₄N₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₁₄N₂O₃(1410633-49-6)
• EPA Substance Registry System: C₁₂H₁₄N₂O₃(1410633-49-6)

Safety Data

• Hazardous Substances Data: 1410633-49-6(Hazardous Substances Data)

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 64328-61-6 (4-butyloxybenzoyl)hydrazine 
• 120-47-8 Ethyl 4-hydroxybenzoate 
• 5365-43-5 ethyl 4-butoxybenzoate 

Downstream Products

• 1630012-94-0 4-butyl-5-(4-butoxyphenyl)-2H-1,2,4-triazole-3(4H)-one 
• 901967-47-3 C₁₆H₂₅N₃O₃ 

Relevant articles and documents

Synthesis and anticonvulsant activity evaluation of 4-butyl-5-(4- alkoxyphenyl)-2H-1,2,4-triazole-3(4H)-ones

A series of 4-butyl-5-(4-alkoxyphenyl)-2H-1,2,4-triazole-3(4H)-ones (6a-6u) was designed and synthesized. The anticonvulsant effects and neurotoxicity of the compounds were evaluated with maximal electroshock test and rotarod test. Among the synthetic compounds, 4-butyl-5-(4-(2-fluorinebenzyl)phenyl)-2H-1,2,4- triazole-3 (4H)-one (6k) was the most potent with ED50 value of 27.4 mg/kg and protective index (PI = TD50/ED50) value of 12.0. Besides the anti-MES efficacy, the potency of compound 6k against seizures induced by pentylenetetrazole (PTZ), 3-mercaptopropionic acid (3-MP), and bicuculline (BIC) was also established, which suggested that the mechanisms of action including enhancing of GABAergic activity might be involved in its anticonvulsant activity.