141318-79-8

Basic information

• Product Name: R-3,4-Diaminobutyric acid 2HCl
• Synonyms: R-3,4-Diaminobutyric acid 2HCl;(R)-3,4-Diaminobutyric acid dihydrochloride;(R)-3,4-diaminobutanoic acid dihydrochloride;REF DUPL: R-3,4-Diaminobutyric acid 2HCl;(3R)-3,4-diaminobutanoic acid,dihydrochloride
• CAS NO: 141318-79-8
• Molecular Formula: C4H12Cl2N2O2
• Molecular Weight: 191.05628
• Mol File: 141318-79-8.mol

Chemical Properties

• Boiling Point: 328.1 °C at 760 mmHg
• Flash Point: 152.2 °C
• Appearance: /
• Vapor Pressure: 3.83E-05mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: R-3,4-Diaminobutyric acid 2HCl(CAS DataBase Reference)
• NIST Chemistry Reference: R-3,4-Diaminobutyric acid 2HCl(141318-79-8)
• EPA Substance Registry System: R-3,4-Diaminobutyric acid 2HCl(141318-79-8)

Safety Data

• Hazardous Substances Data: 141318-79-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
R-3,4-Diaminobutyric acid 2HCl is used as a building block for the synthesis of novel compounds for the treatment of various diseases. Its unique structure and properties make it a valuable component in the development of new pharmaceuticals.
Used in Agrochemical Industry:
R-3,4-Diaminobutyric acid 2HCl is used as a key component in the development of new agrochemicals. Its potential applications in this field include the creation of novel compounds for pest control, crop protection, and other agricultural purposes.
Used in Chemical Research:
R-3,4-Diaminobutyric acid 2HCl is used as a research compound to explore its unique properties and potential applications in various chemical reactions and processes. Its presence in chemical research helps scientists better understand its behavior and interactions with other compounds, paving the way for new discoveries and innovations.

InChI:InChI=1/C4H10N2O2.2ClH/c5-2-3(6)1-4(7)8;;/h3H,1-2,5-6H2,(H,7,8);2*1H/t3-;;/m1../s1

Upstream product

• 141291-26-1 (4R)-4-(carbomethoxymethyl)-imidazolidin-2-one 
• 141291-28-3 (4S)-4-(carbo-t-butoxymethyl)-imidazolidin-2-one 

Relevant articles and documents

Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid

R or S aminocarnitine, R or S phosphonium aminocarnitine and R and S 3,4 diaminobutanoic acid, and their derivatives are prepared using starting from aspartic acid with the same configuration as the desired compounds. This process is advantageous from the industrial point of view in terms of the type of reactants used, the reduced volumes of solvents and the possibility of avoiding purification of the intermediate products.

Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid

A process is described for the preparation of R or S aminocarnitine, R or S phosphonium aminocarnitine and R and S 3,4 diaminobutanoic acid, and their derivatives with the following formula: 1where Y is as described in the attached description, starting from aspartic acid with the same configuration as the desired compounds. This process is advantageous from the industrial point of view in terms of the type of reactants used, the reduced volumes of solvents and the possibility of avoiding purification of the intermediate products.

Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid

A process is described for the preparation of R or S aminocarnitine, R or S phosphonium aminocarnitine and R and S 3,4 diaminobutanoic acid, and their derivatives with the following formula: where Y is as described in the attached description, starting from aspartic acid with the same configuration as the desired compounds. This process is advantageous from the industrial point of view in terms of the type of reactants used, the reduced volumes of solvents and the possibility of avoiding purification of the intermediate products.

Synthesis of (R)-3,4-diaminobutanoic acid by desymmetrization of dimethyl 3-(benzylamino)glutarate through enzymatic ammonolysis

Lipase B from Candida antarctica is shown to be a highly efficient catalyst for the desymmetrization of dimethyl 3-(benzylamino)glutarate (1) through aminolysis and ammonolysis reactions. Using this procedure, enantiopure monoamides are obtained in high yield. The synthetic value of these compounds is demonstrated by the preparation of an enantiopure nonnatural amino acid, i.e. (R)-3,4-diaminobutanoic acid [(+)-12].

A Practical and Stereoconservative Synthesis of (R)-3-Amino-4-(trimethyl-ammonio)butanoate [(R)-Aminocarnitine], and Its Trimethylphosphonium and Simple Ammonium Analogues Starting from D-Aspartic Acid

We have developed a new stereospecific synthesis of (R)-aminocarnitine using D-aspartic acid as the starting material. This strategy, which is simple and amenable to an industrial scale-up, gives the target compound in six steps and in fairly good overall

Synthesis of (3R)- and (3S)-3,4-diamino-butyric acid from L-aspartic acid

A short and convenient synthesis for both enantiomers of GABOB amino-analogue 1a,b is reported, starting from L-aspartic acid. The protected diester 3 is the common intermediate for the synthetic pathway.