141379-91-1Relevant articles and documents
QUINUCLIDINE DERIVATIVES
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, (2008/06/13)
Quinuclidine derivatives of the formula STR1 and the pharmaceutically acceptable salts thereof, wherein m, P, Z, Y, R 1, R. sup.2 and R 3 are as defined below. The compounds are substance P antagonists and, therefore, are useful in treating gastrointestinal disorders, central nervous system disorders, inflammatory diseases, pain and migraine.
Aza-tricyclic substance P antagonists
Lowe III,Drozda,McLean,Bryce,Crawford,Snider,Longo,Nagahisa,Tsuchiya
, p. 2831 - 2840 (2007/10/02)
The synthesis and structure-activity relationships of a series of aza- tricyclic analogs of the quinuclidine substance P (SP) antagonist 1 are described. The SP receptor affinity of these compounds was found to vary according to the size of the new ring fused to the quinuclidine and the mode of fusion. Correlations between receptor affinity and (1) the steric bulk of the newly introduced ring fusion and (2) the dihedral angle between the benzhydryl and benzylamino substituents of these aza-tricyclic compounds were explored.