- Selective derivatization of d-galactose towards a practical synthesis of C-6 l-fucose analogues
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Starting from d-galactose, a convenient protocol is described for the synthesis of l-fucose C-6 analogue, 2,3,4,5-tetra-O-acetyl-5-(1,3-dithiolan-2- yl)-l-galactopyranose, in an overall yield of 40% after 6 steps, making use of stable intermediates. A chemoselective protection/deprotection strategy was studied using TBDMS and TBDPS silyl ethers for protection of d-galactose primary hydroxyl group.
- Pinto, Rui C.,Andrade, Marta M.,Barros, Maria Teresa
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p. 6633 - 6636,4
(2012/12/13)
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