- COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE
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Compounds which have activity at M1 receptor and their uses in medicine Compounds of formula (I) and salts and solvates are provided: wherein R4 is fluoro, R5 is selected from hydrogen, halogen, cyano, C1-6alkyl
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Page/Page column 48
(2010/11/26)
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- BENZOXAZINONE AND BENZOXAZEPINONE OXAZOLIDINONES AS ANTIBACTERIAL AGENTS
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The present invention provides a compound of formula (I) wherein X is a structure of the following formula (i), (ii), (iii), or iv G is O, or S; U is -(CR3R4)n-; W is CH2NHC(=G)R1, CH2NH-het, CH2-G-het, CH2het, C(=O)NHR2; and Y1, Y2 and Y3 are independently CH, or CF. The compounds of the present invention are useful as antibacterial agents.
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Page/Page column 36-37
(2010/11/28)
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- 2-(2-Chloro-6-fluorophenyl)acetamides as potent thrombin inhibitors
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2-(2-Chloro-6-fluorophenyl)acetamides having 2,2-difluoro-2-aryl/heteroaryl-ethylamine P3 and oxyguanidine P1 substituents are potent thrombin inhibitors (Ki = 0.9-33.9 nM). 2-(5-Chloro-pyridin-2-yl)-2,2-difluoroethylamine was the best P3 subst
- Lee, Lily,Kreutter, Kevin D.,Pan, Wenxi,Crysler, Carl,Spurlino, John,Player, Mark R.,Tomczuk, Bruce,Lu, Tianbao
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p. 6266 - 6269
(2008/03/18)
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- Oxazolidinones containing oxindoles as antibacterial agents
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The present invention relates to novel oxazolidinones derivatives of oxindoles of formula I, or a pharmaceutically acceptable salt thereof wherein Y1 is —CH— or —CF—; R1 is —C1-4alkyl, optionally substituted with a fluoro atom, or R1 is —C3-5cycloalkyl; and R2 is —H or —CH3. These compounds are useful as antibacterial agents.
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Page/Page column 17
(2008/06/13)
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- 7-Fluoro-1,3-dihydro-indol-2-one oxazolidinones as antibacterial agents
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The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof wherein R1 is C1-4alkyl, optionally substituted with a fluoro atom, or R1 is a cyclopropyl or cyclopropylmethyl; and Rsu
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Page/Page column 8-9; 11
(2008/06/13)
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- Tricyclic compound or salts thereof, method for producing the same and antimicrobial agent containing the same
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A tricyclic compound represented by the general formula (1) and salts thereof. STR1 A method for producing the tricyclic compound and salts thereof, and an antimicrobial agent containing the tricyclic compound and salts thereof as an active ingredient are
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