Novel and green protocol for the synthesis of 2-iminohydantoins
A novel and green protocol for the synthesis of N-1 and C-5 substituted 2-iminohydantoins has been developed. Methyl N-cyano-N-alkyl/aryl-aminoacetate reacts with aqueous ammonia at room temperature in 10-30 min. The developed protocol does not require any work-up for the isolation or purification of the products; simple filtration can lead to the pure products in good to excellent yields.
Kumar, Vinod,Rana, Hemlata,Kaushik, M. P.
p. 6423 - 6425,3
(2012/12/12)
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