Broadening the chemical scope of laccases: Selective deprotection of N-benzyl groups
Laccase from Trametes versicolor together with TEMPO has been found to be a very efficient system to deprotect N-benzylated primary amines, differing from previously described methods since it uses oxygen as a mild oxidant in aqueous medium. Chemoselective removal of the benzyl group was achieved with excellent yields when secondary amines and alcohol moieties were also present.
Synthesis of multisubstituted furans, pyrroles, and thiophenes via ynolates
An efficient synthetic method for the preparation of multisubstituted furans, thiophenes, and pyrroles using ynolates was developed. This novel formal [4 + 1] annulation by C2-C3 and C3-C4 bond formations Includes cycloaddition, cyclization, decarboxylati
The effect of different amine bases in the Swern oxidation of β-amino alcohols
Swern oxidation of β-amino alcohols containing tertiary amino groups afforded the corresponding α-amino carbonyl compounds in fair to excellent yield. Yields were dependent on the steric requirement of the amine base used for the reaction and were optimiz
Chrisman, William,Singaram, Bakthan
p. 2053 - 2056
(2007/10/03)
Syntheses and X-Ray Crystal Structures of Tricyclic Ketones Containing Trans-Fused Azabicyclooctane Units
Tricyclic ketones containing the trans-fused 3-azabicyclooctane framework were prepared from the reactions of dienes and Cp2ZrBu2, followed by treatment with carbon monoxide.The structures were confirmed by X-ray analysis.
Novel synthesis of nitrogen heterocycles using zirconium-promoted reductive cyclization
Perhydroindole derivatives were prepared from enynes using zirconium-promoted reductive cyclization. The zirconacycles derived from enynes 1 were treated with iodine, isonitriles, oxygen, and carbon monoxide to give various heterocycles. The carbon-zirconium bonds of the zirconacycle could be selectively cleaved by different reagents.
Mori,Uesaka,Saitoh,Shibasaki
p. 5643 - 5649
(2007/10/02)
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