Palladium-Catalyzed N-Arylation of Iminodibenzyls and Iminostilbenes with Aryl- and Heteroaryl Halides
Compounds containing the iminodibenzyl and iminostilbene ring systems are prevalent in medicinal targets and functional materials. Herein, we report palladium-catalyzed conditions for the N-arylation of these ring systems. This protocol could be applied to a variety of (hetero)aryl chloride and bromide substrates, including ones, which are sterically hindered or those containing a variety of functional groups. Use of the fourth-generation palladacycle precatalyst gave good to excellent yields by using low palladium-catalyst loadings (0.1 to 1 mol %).
Huang, Wenliang,Buchwald, Stephen L.
supporting information
p. 14186 - 14189
(2016/09/23)
Palladium-catalyzed double N-arylation to synthesize multisubstituted dibenzoazepine derivatives
Palladium-catalyzed double N-arylation of primary amines with (Z)-1,2-bis(2-bromophenyl)ethenes was investigated. A variety of dibenzoazepine derivatives were synthesized in good to excellent yields.
Zhang, Xiaoyun,Yang, Yuan,Liang, Yun
supporting information
p. 6406 - 6408,3
(2012/12/12)
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