Asymmetric synthesis of diverse glycolic acid scaffolds via dynamic kinetic resolution of α-keto esters
The dynamic kinetic resolution of α-keto esters via asymmetric transfer hydrogenation has been developed as a technique for the highly stereoselective construction of structurally diverse β-substituted-α- hydroxy carboxylic acid derivatives. Through the development of a privileged m-terphenylsulfonamide for (arene)RuCl(monosulfonamide) complexes with a high affinity for selective α-keto ester reduction, excellent levels of chemo-, diastereo-, and enantiocontrol can be realized in the reduction of β-aryl- and β-chloro-α-keto esters.
Steward, Kimberly M.,Corbett, Michael T.,Goodman, C. Guy,Johnson, Jeffrey S.
supporting information
p. 20197 - 20206
(2013/02/23)
More Articles about upstream products of 1415391-66-0