141543-63-7 Usage
Uses
Used in Pharmaceutical Industry:
1-(5-Isoquinolinesulfonyl)piperazine Hydrochloride is used as a pharmaceutical compound for its ability to inhibit protein kinase C and cyclic nucleotide-dependent protein kinases. This makes it a potential candidate for the development of drugs targeting various diseases and conditions that involve the dysregulation of these kinases, such as certain types of cancer and inflammatory disorders.
Used in Research Applications:
In the field of scientific research, 1-(5-Isoquinolinesulfonyl)piperazine Hydrochloride serves as a valuable tool for studying the roles and mechanisms of action of protein kinases. By inhibiting these enzymes, researchers can gain insights into their functions and the pathways they regulate, which can ultimately contribute to the development of novel therapeutic strategies.
Used in Drug Discovery and Development:
The potent inhibition of protein kinases by 1-(5-Isoquinolinesulfonyl)piperazine Hydrochloride makes it a promising starting point for the design and synthesis of new drugs. Researchers can use this compound as a lead molecule to develop more selective and effective inhibitors, which could be applied in the treatment of various diseases associated with abnormal kinase activity.
Check Digit Verification of cas no
The CAS Registry Mumber 141543-63-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,1,5,4 and 3 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 141543-63:
(8*1)+(7*4)+(6*1)+(5*5)+(4*4)+(3*3)+(2*6)+(1*3)=107
107 % 10 = 7
So 141543-63-7 is a valid CAS Registry Number.
141543-63-7Relevant articles and documents
5-Isoquinolinesulfonamide derivatives. III. Synthesis and vasodilatory activity of 1-(5-isoquinolinesulfonyl)piperazine derivatives
Morikawa,Sone,Asano
, p. 770 - 773 (2007/10/02)
On the basis of a hypothesis that cyclization and alkylation of the diamine part in formula 1 may give highly active compounds, a new series of 5-isoquinolinesulfonamide derivatives, shown as formula 2, were prepared from cyclic diamines. Their vasodilatory effects were subsequently evaluated in vivo according to the increase in arterial blood flow after the formulas were injected locally to the femoral and/or vertebral arteries of dogs. Cyclization of the diamine structure in formula 1 gave very potent vasodilators: 6 and 14. Acylation and sulfonylation of terminal amino nitrogen afforded much less potent compounds. In contrast to the hypothesis, alkylation on the ring carbon and the terminal nitrogen of the cyclic amine afforded less active compounds except for compound 11. The most active compounds, 6, 11 and 14, showed more potent vasodilatory effects and more selective activity to the vertebral artery than either trapidil or diltiazem.
