141580-71-4

Basic information

• Product Name: 2-(PYRID-2-YLOXY)BENZALDEHYDE
• Synonyms: 2-(PYRID-2-YLOXY)BENZALDEHYDE;2-(pyridin-2-yloxy)benzaldehyde
• CAS NO: 141580-71-4
• Molecular Formula: C12H9NO2
• Molecular Weight: 199.20536
• Mol File: 141580-71-4.mol

Chemical Properties

• Boiling Point: 324.9°Cat760mmHg
• Flash Point: 150.3°C
• Appearance: /
• Density: 1.207g/cm³
• Vapor Pressure: 0.000238mmHg at 25°C
• Refractive Index: 1.614
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-(PYRID-2-YLOXY)BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(PYRID-2-YLOXY)BENZALDEHYDE(141580-71-4)
• EPA Substance Registry System: 2-(PYRID-2-YLOXY)BENZALDEHYDE(141580-71-4)

Safety Data

• Hazardous Substances Data: 141580-71-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(PYRID-2-YLOXY)BENZALDEHYDE is used as a precursor in the synthesis of various pharmaceuticals for its ability to form heterocyclic compounds, which are essential in the development of new drugs.
Used in Perfumery and Fragrance Industry:
2-(PYRID-2-YLOXY)BENZALDEHYDE is used as a component in perfumery and fragrance formulations for its strong odor, contributing to the creation of unique and complex scents.
Used in Chemical Research:
2-(PYRID-2-YLOXY)BENZALDEHYDE is used in chemical research for its potential biological and pharmacological activities, allowing scientists to explore its properties and applications in the development of new compounds and materials.

InChI:InChI=1/C12H9NO2/c14-9-10-5-1-2-6-11(10)15-12-7-3-4-8-13-12/h1-9H

Upstream product

• 109-04-6 2-bromo-pyridine 
• 90-02-8 salicylaldehyde 

Relevant articles and documents

C-H functionalization of phenols using combined ruthenium and photoredox catalysis: In situ generation of the oxidant

A combination of ruthenium and photoredox catalysis allowed the ortho olefination of phenols. Using visible light, the direct C-H functionalization of o-(2-pyridyl) phenols occurred, and diverse phenol ethers were obtained in good yields. The regeneration of the ruthenium catalyst was accomplished by a photoredox-catalyzed oxidative process.

COMPOUNDS FOR AND METHODS OF TREATING DISEASES

The present invention provides compounds that modulate biological metals and to pharmaceutical compositions containing such compounds. The invention particularly relates to imidazo[1,5-a]pyridine compounds that modulate iron and are useful for the treatment of diseases, particularly neurological diseases such as Parkinson's disease (PD), Alzheimer's 5 disease (AD), Alzheimer-type dementia, Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and multiple system atrophy (MSA).

NHC-Organocatalyzed CAr?O Bond Cleavage: Mild Access to 2-Hydroxybenzophenones

A Truce–Smiles rearrangement of acyl-anion equivalents generated by N-heterocyclic carbene (NHC) catalysis has been achieved. The developed method includes CAr?O, CAr?S, or CAr?N bond cleavage for the formation of a CAr?C bond and enables access to 2-hydroxybenzophenones, an important structural motif that is present in several bioactive natural products. By utilizing this procedure, the alkaloid taxilamine was synthesized in three steps. DFT calculations and control experiments support a classical SNAr mechanism with a catalyst-bound Meisenheimer-type intermediate. The method features mild reaction conditions, excellent functional-group tolerance, and a broad substrate scope, including various classes of (hetero)arenes.

ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY

Compounds of the structure where p and q are zero or one, but cannot both be the same, M is a pharmaceutically acceptable cation or a metabolically cleavable group, B is a valence bond or a straight or branched alkylene group, R is alkyl, cycloalkyl or --NR1 R2, where R1 and R2 are hydrogen, alkyl, cycloalkyl or alkanoyl, and A is optionally substituted carbocyclic aryl, furyl, benzo[b]furyl, thienyl, or benzo[b]thienyl are potent inhibitors of lipoxygenase enzymes and thus inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.