A catalytic asymmetric isatin-involved Povarov reaction: Diastereo- and enantioselective construction of spiro[indolin-3,2'-quinoline] scaffold
The first catalytic asymmetric isatin-involved Povarov reaction has been established. This method provides an unprecedented approach to access the enantioenriched spiro[indolin-3,2'-quinoline] scaffold with concomitant creation of two quaternary stereogenic centers in high yields and excellent stereoselectivities (all >99:1 dr's, up to 97% ee).