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2,6-Difluoro-4-iodoaniline is a chemical compound that belongs to the class of aniline derivatives, specifically substituted anilines. It is characterized by its yellow to brown solid appearance and a molecular formula of C6H5F2IN. This versatile chemical is known for its role in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and dyes.

141743-49-9

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141743-49-9 Usage

Uses

Used in Pharmaceutical Industry:
2,6-Difluoro-4-iodoaniline is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs with specific therapeutic properties. Its unique structure allows for the creation of molecules with targeted effects on biological systems.
Used in Agrochemical Industry:
In the agrochemical sector, 2,6-Difluoro-4-iodoaniline serves as a building block in the production of agrochemicals, which are essential for enhancing crop protection and yield. Its incorporation into these compounds can lead to more effective and targeted pest control solutions.
Used in Dye Industry:
2,6-Difluoro-4-iodoaniline is utilized as a key intermediate in the manufacture of dyes, where its chemical properties contribute to the creation of vibrant and stable colorants for various applications, including textiles, plastics, and printing inks.
Used in Polymer and Resin Production:
2,6-DIFLUORO-4-IODOANILINE is also used as a building block in the development of polymers and resins, which are crucial in the production of various materials used in industries such as automotive, construction, and electronics.
Used in Research and Development:
2,6-Difluoro-4-iodoaniline is employed in research and development settings to explore its potential applications across different industries. Its unique properties make it a valuable candidate for further investigation and innovation.
It is crucial to handle 2,6-Difluoro-4-iodoaniline with care and follow proper safety protocols during its use, storage, and disposal to mitigate any potential hazards associated with this chemical compound.

Check Digit Verification of cas no

The CAS Registry Mumber 141743-49-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,1,7,4 and 3 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 141743-49:
(8*1)+(7*4)+(6*1)+(5*7)+(4*4)+(3*3)+(2*4)+(1*9)=119
119 % 10 = 9
So 141743-49-9 is a valid CAS Registry Number.
InChI:InChI=1/C6H4F2IN/c7-4-1-3(9)2-5(8)6(4)10/h1-2H,10H2

141743-49-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,6-Difluoro-4-iodoaniline

1.2 Other means of identification

Product number -
Other names 2,6-DIFLUORO-4-IODOANILINE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:141743-49-9 SDS

141743-49-9Upstream product

141743-49-9Relevant articles and documents

Reversible Stereoselective Folding/Unfolding Fueled by the Interplay of Photoisomerism and Hydrogen Bonding

Opie, Christopher R.,Kumagai, Naoya,Shibasaki, Masakatsu

, p. 3349 - 3353 (2017)

A linear molecular architecture equipped with complementary three-fold hydrogen-bonding units embedded with a photoswitchable trans-tetrafluoroazobenzene moiety was synthesized. The transto cis photoisomerism of the azobenzene unit induced drastic changes

Active ester functionalized azobenzenes as versatile building blocks

Schultzke, Sven,Staubitz, Anne,Walther, Melanie

supporting information, (2021/07/12)

Azobenzenes are important molecular switches that can still be difficult to functionalize selectively. A high yielding Pd-catalyzed cross-coupling method under mild conditions for the introduction of NHS esters to azobenzenes and diazocines has been established. Yields were consistently high with very few exceptions. The NHS functionalized azobenzenes react with primary amines quantitatively. These amines are ubiquitous in biological systems and in material science.

COMPOSITION AND METHOD FOR MANUFACTURING RESINS

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Paragraph 0182, (2021/05/07)

Certain embodiments of the invention described herein comprise a composition of matter, and method for preparing the same, which provide the benefits of pre-reaction molecular configuration favoring high liquidity properties, and post-reaction configurati

Molecular Hybridization-Inspired Optimization of Diarylbenzopyrimidines as HIV-1 Nonnucleoside Reverse Transcriptase Inhibitors with Improved Activity against K103N and E138K Mutants and Pharmacokinetic Profiles

Han, Sheng,Sang, Yali,Wu, Yan,Tao, Yuan,Pannecouque, Christophe,De Clercq, Erik,Zhuang, Chunlin,Chen, Fen-Er

, (2019/11/11)

Molecular hybridization is a powerful strategy in drug discovery. A series of novel diarylbenzopyrimidine (DABP) analogues were developed by the hybridization of FDA-approved drugs etravirine (ETR) and efavirenz (EFV) as potential HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs). Substituent modifications resulted in the identification of new DABPs with the combination of the strengths of the two drugs, especially compound 12d, which showed promising activity toward the EFV-resistant K103N mutant. 12d also had a favorable pharmacokinetic (PK) profile with liver microsome clearances of 14.4 μL/min/mg (human) and 33.2 μL/min/mg (rat) and an oral bioavailability of 15.5% in rat. However, its activity against the E138K mutant was still unsatisfactory; E138K is the most prevalent NNRTI resistance-associated mutant in ETR treatment. Further optimizations resulted in a highly potent compound (12z) with no substituents on the phenyl ring and a 2-methyl-6-nitro substitution pattern on the 4-cyanovinyl-2,6-disubstitued phenyl motif. The antiviral activity of this compound was much higher than those of ETR and EFV against the WT, E138K, and K103N variants (EC50 = 3.4, 4.3, and 3.6 nM, respectively), and the cytotoxicity was decreased while the selectivity index (SI) was increased. In particular, this compound exhibited acceptable intrinsic liver microsome stability (human, 34.5 μL/min/mg; rat, 33.2 μL/min/mg) and maintained the good PK profile of its parent compound EFV and showed an oral bioavailability of 16.5% in rat. Molecular docking and structure-activity relationship (SAR) analysis provided further insights into the binding of the DABPs with HIV-1 reverse transcriptase and provided a deeper understanding of the key structural features responsible for their interactions.

O -fluoroazobenzenes as readily synthesized photoswitches offering nearly quantitative two-way isomerization with visible light

Bleger, David,Schwarz, Jutta,Brouwer, Albert M.,Hecht, Stefan

supporting information, p. 20597 - 20600 (2013/02/22)

Azobenzene functionalized with ortho-fluorine atoms has a lower energy of the n-orbital of the Z-isomer, resulting in a separation of the E and Z isomers' n→π* absorption bands. Introducing para-substituents allows for further tuning of the absorption spe

Synthesis of fluorine-containing molecular rotors and their assembly on gold nanoparticles

Thibeault, Dominic,Auger, Michele,Morin, Jean-Francois

experimental part, p. 3049 - 3067 (2010/08/07)

A series of eight rotors containing thiol groups for attachment to gold surfaces and fluorine atoms for solid-state 19F NMR spectroscopy have been prepared through linear, multistep synthesis. The common rotating part of the rotors (rotator), c

Photochemistry of fluorinated 4-iodophenylnitrenes: Matrix isolation and spectroscopic characterization of phenylnitrene-4-yls

Grote, Dirk,Sander, Wolfram

supporting information; experimental part, p. 7370 - 7382 (2010/02/28)

(Chemical Equation Presented) The photochemistry of a series of fluorinated p-iodophenyl azides 2 has been investigated using matrix isolation IR and EPR spectroscopy. In all cases, the corresponding phenylnitrenes 1 were formed as primary photoproducts. Further irradiation of the nitrenes 1 resulted in the formation of azirines 3, ketenimines 4, and nitreno radicals 5. The yield of 5 depends on the number of ortho fluorine substituents: with two ortho fluorine atoms the highest yield is observed, whereas without fluorine atoms the yield is too low for IR spectroscopic detection. The interconversion between the isomers 1, 3, and 4 proved to be rather complex. If the fluorine atoms are distributed unsymmetrically, two isomers of azirines 3 and ketenimines 4 can be formed. The yields of these isomers depend critically on the irradiation conditions. 2009 American Chemical Society.

HIV INHIBITING 1,2,4-TRIAZIN-6-ONE DERIVATIVES

-

Page/Page column 54, (2008/06/13)

The present invention relates to HIV replication inhibitors of formula (I) a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine or a stereochemically isomeric form thereof, wherein ring A and ring B represent phenyl, pyridyl, pyridaz

NOVEL COMPOUNDS, ISOMER THEREOF OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST; AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

-

Page/Page column 77, (2010/11/23)

This present invention relates to novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRPV1 )antagonist; and a pharmaceutical composition containing the same. The present invention

HIV INHIBITING 1,2,4-TRIAZINES

-

Page 54, (2008/06/13)

The present invention relates to HIV replication inhibitors of formula (I) as defined in the specification their use as a medicine, their processes for preparation and pharmaceutical compositions comprising them.

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