141799-76-0

Basic information

• Product Name: 1-butyl-3-{2-[3-(5-ethyl-4-phenyl-1H-imidazol-1-yl)propoxy]-6-methylphenyl}urea
• CAS NO: 141799-76-0
• Molecular Formula: C₂₆H₃₄N₄O₂
• Molecular Weight: 434.5738
• Mol File: 141799-76-0.mol

Chemical Properties

• Boiling Point: 637.4°C at 760 mmHg
• Flash Point: 339.3°C
• Density: 1.11g/cm³
• Vapor Pressure: 3.78E-16mmHg at 25°C
• Refractive Index: 1.576
• CAS DataBase Reference: 1-butyl-3-{2-[3-(5-ethyl-4-phenyl-1H-imidazol-1-yl)propoxy]-6-methylphenyl}urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-butyl-3-{2-[3-(5-ethyl-4-phenyl-1H-imidazol-1-yl)propoxy]-6-methylphenyl}urea(141799-76-0)
• EPA Substance Registry System: 1-butyl-3-{2-[3-(5-ethyl-4-phenyl-1H-imidazol-1-yl)propoxy]-6-methylphenyl}urea(141799-76-0)

Safety Data

• Hazardous Substances Data: 141799-76-0(Hazardous Substances Data)

Usage

Chemical structure

A urea derivative with a complex structure containing a butyl chain, two benzene rings, an imidazole ring, and a propoxy group attached to one of the benzene rings.

Potential applications

Medicinal chemistry, acting as a ligand for biological targets or as a starting material for the synthesis of other biologically active compounds.

Biological activities

Chemicals with complex structures like this one are of interest for their potential biological activities and pharmacological properties.

Molecular weight

Approximately 452.61 g/mol (calculated from the molecular formula).

Functional groups

Urea, butyl chain, benzene rings, imidazole ring, and propoxy group.

Stereochemistry

The compound may have stereoisomers due to the presence of chiral centers in the butyl chain and the imidazole ring.

Solubility

The compound's solubility is not provided, but it may be influenced by the presence of the urea, imidazole, and propoxy groups.

Stability

The stability of the compound is not provided, but it may be affected by factors such as temperature, pH, and exposure to light or air.

Upstream product

• 141816-27-5 2-{3-(5-ethyl-4-phenyl-1H-imidazol-1-yl)propoxy}-6-methyl aniline 
• 111-36-4 n-butyl isocyanide 
• 1025887-51-7 N-(1-Benzoyl-propyl)-N-[3-(3-methyl-2-nitro-phenoxy)-propyl]-formamide 
• 141816-26-4 3-<3-(5-ethyl-4-phenyl-1H-imidazol-1-yl)propoxy>-2-nitrotoluene 
• 141816-24-2 3-<3-(diformylamino)propoxy>-2-nitrotoluene 
• 141816-25-3 3-(3-formamidopropoxy)-2-nitrotoluene 
• 141816-23-1 3-(3-chloropropoxy)-2-nitrotoluene 
• 4920-77-8 3-methyl-2-nitrophenol 

Relevant articles and documents

Trisubstituted benzene derivatives, composition and methods of treatment

A benzene, pyridine or pyrimidine derivative having the below shown formula is novel and useful as an anti-arteriosclerotic agent. STR1 wherein R1 stands for a lower alkyl group, an amino group which may be substituted, or the like; R2 stands for a group represented by the formula: STR2 (wherein R16 stands for an alkyl group having 1 to 6 carbon atoms, or the like) or the like; R3 stands for a group represented by the formula: --O--(CH2)m --Y (Y stands for an imidazolyl or piperazinyl group, or the like and m is 1 to 6) or the like; R5 stands for a hydrogen atom, a lower alkyl group, or the like; A stands for a group represented by the formula: STR3 (wherein R6 stands for a hydrogen atom, a lower alkyl group, or the like), --N=, or the like; and B stands for a group represented by the formula: STR4 (wherein R4 stands for a hydrogen or the like), --N=, or the like.

Structure-activity relationship of a series of phenylureas linked to 4- phenylimidazole. Novel potent inhibitors of acyl-CoA:cholesterol O- acyltransferase with antiatherosclerotic activity. 2

In our continuing search to find systemically bioavailable ACAT (acyl- CoA:cholesterol O-acyl-transferase) inhibitors with more potent antiatherosclerotic effect than N-[2-(dimethylamino)-6-[3-(5-methyl-4- phenyl-1H-imidazol-1-yl)propoxy]phenyl]-N'-pentyl