Welcome to LookChem.com Sign In|Join Free

CAS

  • or

1418131-46-0

RSC-133 is an indole compound that promotes the reprogramming of human somatic cells to pluripotent stem cells. Specifically, when used at 10 μM with four standard reprogramming factors, it increases the number of human foreskin fibroblasts that express the stem cell marker alkaline phosphatase. RSC-133 induces pluripotency by both down-regulating inducers of cellular senescence and inhibiting DNA methyltransferase and histone deacetylase activities.

1418131-46-0 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 1418131-46-0 Structure

  • Basic information

    1. Product Name: RSC 133
    2. Synonyms: RSC 133;3-[[(2E)-3-(1H-Indol-3-yl)-1-oxo-2-propen-1-yl]amino]-benzamide;Reprogramming stimulating compound 133;3-[[(E)-3-(1H-indol-3-yl)prop-2-enoyl]amino]benzamide
    3. CAS NO:1418131-46-0
    4. Molecular Formula: C18H15N3O2
    5. Molecular Weight: 305.3306
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1418131-46-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 653.7±55.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: white to light brown/
    5. Density: 1.372±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: ?20°C
    8. Solubility: DMSO: soluble20mg/mL, clear
    9. PKA: 13.22±0.70(Predicted)
    10. CAS DataBase Reference: RSC 133(CAS DataBase Reference)
    11. NIST Chemistry Reference: RSC 133(1418131-46-0)
    12. EPA Substance Registry System: RSC 133(1418131-46-0)

  • Safety Data

    1. Hazard Codes: Xn,N
    2. Statements: 22-51/53
    3. Safety Statements: 61
    4. RIDADR: UN 3077 9 / PGIII
    5. WGK Germany: 3
    6. RTECS:
    7. HazardClass: N/A
    8. PackingGroup: N/A
    9. Hazardous Substances Data: 1418131-46-0(Hazardous Substances Data)

1418131-46-0 Usage

Uses

RSC 133 is a potent chemical booster for human somatic cell reprogramming. RSC 133 facilitates the maintenance of pluripotent human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs).

Check Digit Verification of cas no

The CAS Registry Mumber 1418131-46-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,1,8,1,3 and 1 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1418131-46:
(9*1)+(8*4)+(7*1)+(6*8)+(5*1)+(4*3)+(3*1)+(2*4)+(1*6)=130
130 % 10 = 0
So 1418131-46-0 is a valid CAS Registry Number.

1418131-46-0 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail

  • Sigma

  • (SML1113)  RSC133  ≥98% (HPLC)

  • 1418131-46-0

  • SML1113-5MG

  • 983.97CNY

  • Detail

  • Sigma

  • (SML1113)  RSC133  ≥98% (HPLC)

  • 1418131-46-0

  • SML1113-25MG

  • 3,970.98CNY

  • Detail

1418131-46-0Downstream Products

1418131-46-0Relevant articles and documents

NOVEL LOW-MOLECULE COMPOUND FOR PROMOTING PLURIPOTENT STEM CELL GENERATION, MAINTENANCE, AND PROLIFERATION, AND COMPOSITION AND CULTURING METHOD CONTAINING SAME

-

Paragraph 0040; 0126; 0134-0137, (2014/09/29)

According to the present invention, when the novel low-molecular-weight compound RSC-133 is added in a culture process for producing reprogrammed pluripotent stem cells from human differentiated cells, it can increase the efficiency of reprogramming and c

A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells

Lee, Jungwoon,Xia, Yan,Son, Mi-Young,Jin, Guanghai,Seol, Binna,Kim, Min-Jeong,Son, Myung Jin,Do, Misol,Lee, Minho,Kim, Dongsup,Lee, Kyeong,Cho, Yee Sook

supporting information, p. 12509 - 12513 (2013/02/23)

Booster of pluripotency: RSC133, a new synthetic derivative of indoleacrylic acid/indolepropionic acid, exhibits dual activity by inhibiting histone deacetylase and DNA methyltransferase. Furthermore it potently improves the reprogramming of human somatic

INDOL DERIVATIVES, THE METHOD FOR PREPARING THEREOF AND COMPOSITION FOR THE PREVENTION AND TREATMENT OF METABOLIC DISORDER CONTAINING THE SAME AS AN ACTIVE INGREDIENT

-

Page/Page column 23-24, (2010/11/30)

Disclosed are indole derivatives,, a preparation method thereof, and a composition for the prevention and treatment of metabolic diseases, containing the same as an active ingredient. The indole derivatives have inhibitory activity against DGAT (diacylgly

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 1418131-46-0