141814-57-5

Basic information

• Product Name: (4-Methylmorpholin-2-yl)methanamine
• Synonyms: 2-Morpholinemethanamine,4-methyl-(9CI);(4-METHYLMORPHOLIN-2-YL)METHANAMINE;4-Methyl-2-aminomethylmorpholine;1-(4-methyl-2-morpholinyl)methanamine(SALTDATA: FREE);4-Methyl-2-morpholinemethanamine 2HCl
• CAS NO: 141814-57-5
• Molecular Formula: C₆H₁₄N₂O
• Molecular Weight: 130.19
• Product Categories: AMINETERTIARY
• Mol File: 141814-57-5.mol

Chemical Properties

• Boiling Point: 189 ºC
• Flash Point: 68 ºC
• Appearance: /
• Density: 0.976
• Vapor Pressure: 0.592mmHg at 25°C
• Refractive Index: 1.46
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: (4-Methylmorpholin-2-yl)methanamine(CAS DataBase Reference)
• NIST Chemistry Reference: (4-Methylmorpholin-2-yl)methanamine(141814-57-5)
• EPA Substance Registry System: (4-Methylmorpholin-2-yl)methanamine(141814-57-5)

Safety Data

• Hazardous Substances Data: 141814-57-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(4-Methylmorpholin-2-yl)methanamine is used as a chemical intermediate for the synthesis of various pharmaceuticals, leveraging its unique properties and reactivity in organic chemistry to facilitate the creation of new drug molecules.
Used in Organic Synthesis:
(4-Methylmorpholin-2-yl)methanamine is utilized as a versatile building block in organic synthesis, contributing to the development of a wide range of organic compounds due to its structural and functional characteristics.
While the provided materials do not specify particular applications beyond its use as an intermediate in pharmaceuticals and organic synthesis, the compound's properties suggest potential uses in various chemical reactions and industries where specific organic compounds are required.

InChI:InChI=1/C6H14N2O/c1-8-2-3-9-6(4-7)5-8/h6H,2-5,7H2,1H3

Upstream product

• 791006-53-6 2-{2-Hydroxy-3-[(2-hydroxy-ethyl)-methyl-amino]-propyl}-isoindole-1,3-dione 

Downstream Products

• 141815-51-2 4-amino-5-chloro-2-methoxy-N-<(4-methyl-2-morpholinyl)methyl>benzamide 
• 141814-93-9 4-Amino-5-chloro-2-ethoxy-N-(4-methyl-morpholin-2-ylmethyl)-benzamide 
• 1332710-62-9 4-[4-Fluoro-2-(tetrahydro-pyran-4-yloxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (4-methyl-morpholin-2-ylmethyl)-amide trifluoracetate 
• 1332710-61-8 C₂₅H₃₀FN₅O₄S 

Relevant articles and documents

Synthesis of 2-substituted morpholines from dihydroxyalkylsulfamates

2-Substituted morpholines and hexahydro-1,4-oxazepines were prepared by cyclodehydration of potassium dihydroxyalkylsulfamates in concentrated sulfuric acid.

Novel benzamides as selective and potent gastrokinetic agents. III. Synthesis and structure-activity relationships of 4-amino-5-chloro-2-methoxy- and 2-ethoxy-N-[(4-substituted 2-morpholinyl)methyl]-benzamides

A series of 4-amino-5-chloro-2-methoxy- and 2-ethoxy-N-[(4-substituted 2-morpholinyl)methyl]benzamides (11-44) were prepared and evaluated for gastrokinetic activity by determining their effects on the gastric emptying of phenol red semisolid meal in rats. The N-4 substituent includes alkyl, phenoxyalkyl, (4-fluorobenzoyl)alkyl, and heteroarylmethyl groups. The benzamide derivatives, having an isopropyl, isoamyl, neopentyl, 3-(4-chlorophenoxy)propyl, or pyridylmethyl group at N-4, showed potent in vivo gastric emptying activity. In particular, 4-amino-5-chloro-2-ethoxy-N-[[4-(3-pyridylmethyl)-2-morpholinyl]methyl ]benzamide (57b) was equipotent to the 4-fluorobenzyl analogue 1b (AS-4370 as its citrate) in the gastrokinetic activity on phenol red semisolid meal in rats and mice, and on resin pellet solid meal in rats. Moreover, compound 57b was free from dopamine D2 receptor antagonistic activity in both in vitro ([3H]spiperone binding) and in vivo (apomorphine-induced emesis in dogs) tests. Structure-activity relationships of compounds with various substituents at N-4 are also discussed.