- Improvement of solid material for affinity resins by application of long PEG spacers to capture the whole target complex of FK506
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Solid materials for affinity resins bearing long PEG spacers between a functional group used for immobilization of a bio-active compound and the solid surface were synthesized to capture not only small target proteins but also large and/or complex target proteins. Solid materials with PEG1000 or PEG2000 as spacers, which bear a benzenesulfonamide derivative, exhibited excellent selectivity between the specific binding protein carbonic anhydrase type II (CAII) and non-specific ones. These materials also exhibited efficacy in capturing a particular target at a maximal amount. Affinity resins using solid materials with PEG1000 or PEG2000 spacers, bear a FK506 derivative, successfully captured the whole target complex of specific binding proteins at the silver staining level, while all previously known affinity resins with solid materials failed to achieve this objective. These novel affinity resins captured other specific binding proteins such as dynamin and neurocalcin δ as well.
- Mabuchi, Miyuki,Shimizu, Tadashi,Ueda, Masahiro,Mitamura, Kuniko,Ikegawa, Shigeo,Tanaka, Akito
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supporting information
p. 2788 - 2792
(2015/06/08)
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- Nail varnish composition comprising at least one film-forming gradient copolymer and cosmetic process for making up and/or caring for the nails
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A nail varnish composition comprising, in a cosmetically acceptable medium, at least one film-forming gradient copolymer comprising at least two different monomeric units and exhibiting a mass polydispersity index (PI) of less than or equal to 2.5, the composition being capable of forming a film having an adhesion corresponding to a detachment percentage of less than 45%; a cosmetic process for making up and/or caring for the nails comprising the application to the nails of the cosmetic composition.
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- Disinfectant polymeric coatings for hard surfaces
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Liquid disinfectant compositions are disclosed which can be used to surface-coat substrates with polymeric films which are adherent, water-resistant and which can impart prolonged germicidal properties to the treated surfaces.
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- SYNTHESIS OF ACRYLIC ESTERS BY LIPASE
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Various acrylic esters were synthesized by the transesterification of vinyl acrylate with various alcohols.The yield of acrylic esters was about 40 and 66percent with n-hexyl and β-phenethyl alcohol, respectively.
- Ikeda, Isao,Tanaka, Jun,Suzuki, Kimihiro
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p. 6865 - 6866
(2007/10/02)
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- Nail polishes
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New nail polish compositions including a resin, a plasticizer, a solvent system, a filming agent, and optionally colorants, wherein the resin is a copolymer of methyl methacrylate and hexyl methacrylate.
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