Stereo- and regiocontrolled syntheses of exomethylenic cyclohexane β-amino acid derivatives
Cyclohexane analogues of the antifungal icofungipen [(1R,2S)-2-amino-4-methylenecy clopentanecarboxylic acid] were selectively synthesized from unsaturated bicyclic β-lactams by transformation of the ring olefinic bond through three different regio- and s
Kiss, Loránd,Forró, Eniko,Orsy, Gy?rgy,ábrahámi, Renáta,Fül?p, Ferenc
p. 21094 - 21101
(2016/01/25)
The first direct enzymatic hydrolysis of alicyclic β-amino esters: A route to enantiopure cis and trans β-amino acids
The first direct enzymatic method is reported for the synthesis of cis and trans βamino acid enantiomers through the lipase-catalyzed enantioselective hydrolysis of alicyclic β esters in organic media. High enantioselectivities (E usually > 001) were observed when the Candida antarctica lipase B catalyzed reactions were performed with H2O (0.5 equivalents) in iP iPr2O at 5°C. The resolved products, obtained in good yields (≥42%), could be easily separated.
Forro, Eniko,Fueloep, Ferenc
p. 6397 - 6401
(2008/02/13)
Advanced procedure for the enzymatic ring opening of unsaturated alicyclic β-lactams
Enantiopure β-amino acids 1a-4a and β-lactams 1b-4b were prepared simultaneously through the lipolase-catalysed enantioselective ring opening of unsaturated racemic β-lactams (±)-1-(±)-4. High enantioselectivities (E>200) were observed when the reactions
Forro, Eniko,Fueloep, Ferenc
p. 2875 - 2880
(2007/10/03)
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