142044-85-7

Basic information

• Product Name: 1-(2-BROMO-4-METHYL-PHENYL)-1H-PYRROLE
• Synonyms: 1-(2-BROMO-4-METHYL-PHENYL)-1H-PYRROLE
• CAS NO: 142044-85-7
• Molecular Formula: C₁₁H₁₀BrN
• Molecular Weight: 236.11
• Mol File: 142044-85-7.mol

Chemical Properties

• Boiling Point: 307.3±35.0 °C(Predicted)
• Appearance: /
• Density: 1.34±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -5.90±0.70(Predicted)
• CAS DataBase Reference: 1-(2-BROMO-4-METHYL-PHENYL)-1H-PYRROLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-BROMO-4-METHYL-PHENYL)-1H-PYRROLE(142044-85-7)
• EPA Substance Registry System: 1-(2-BROMO-4-METHYL-PHENYL)-1H-PYRROLE(142044-85-7)

Safety Data

• Hazardous Substances Data: 142044-85-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
1-(2-BROMO-4-METHYL-PHENYL)-1H-PYRROLE is utilized as a building block in the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Production:
In the agrochemical industry, 1-(2-BROMO-4-METHYL-PHENYL)-1H-PYRROLE serves as a crucial intermediate in the creation of pesticides and other agricultural chemicals. Its role in these applications is to enhance the effectiveness and selectivity of these products, thereby improving crop protection.
Used in Materials Science:
1-(2-BROMO-4-METHYL-PHENYL)-1H-PYRROLE is also employed in materials science for its potential to contribute to the development of new materials with specific properties. Its unique molecular structure can influence the characteristics of materials in areas such as polymer science, nanotechnology, and composite material development.
Used in Organic Synthesis:
As an intermediate in organic synthesis, 1-(2-BROMO-4-METHYL-PHENYL)-1H-PYRROLE is used to produce a variety of organic compounds. Its reactivity and functional groups make it a versatile component in the synthesis of complex organic molecules for various applications across different industries.

Upstream product

• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 583-68-6 2-bromo-p-toluidine 

Downstream Products

• 142045-46-3 1-(2-bromo-4-methyl-phenyl)-1H-pyrrole-2-carbaldehyde 
• 142045-04-3 1-(2-bromo-4-methylphenyl)pyrrole-2-carbonitrile 

Relevant articles and documents

A solvent-free manganese(II) -catalyzed Clauson-Kaas protocol for the synthesis of N-aryl pyrroles under microwave irradiation

The first manganese-catalyzed modified Clauson-Kaas reaction for N-substituted pyrrole synthesis using 2,5-dimethoxytetrahydrofuran with variously substituted aromatic amines has been developed (up to 89% yield). This interesting neat strategy is free from additives including co-catalysts, ligands, and acids. Relatively low cost, environmentally benign, and handy Mn(NO3)2·4H2O is employed as the catalyst under microwave conditions with a very short reaction time (20?min). The above qualities attest to the green nature of this reaction.

Construction of benzo-fused indolizines, pyrrolo[1,2-a]quinolines via alkyne-carbonyl metathesis

The strategic use of a sequential Sonogashira coupling/intramolecular alkyne-carbonyl metathesis process for the synthesis of a pyridine ring from 1-(2-haloaryl)-1H-pyrrole-2-carbaldehydes allowed ready access to diverse novel benzo-fused indolizines, pyr

One-Pot Synthesis of Pyrrolo[1,2- a ]quinoxaline Derivatives via a Copper-Catalyzed Aerobic Oxidative Domino Reaction

A copper-catalyzed process for the synthesis of pyrrolo[1,2-a]quinoxalines from readily available α-amino acids and 1-(2-halophenyl)-1H-pyrroles is described. Different functional groups were well tolerated to give the corresponding products.

Palladium-catalyzed annulation of aryl heterocycles with strained alkenes

An annulation reaction proceeding by the intermolecular addition of an arylpalladium(II) halide across a strained alkene, followed by an intramolecular C-H functionalization of a pendant heterocycle is described. A variety of polycyclic heterocycles have

ANGIOTENSIN II ANTAGONIZING HETEROCYCLIC DERIVATIVES

The invention relates to compounds of the formula STR1 wherein STR2 represents a condensed or uncondensed imidazolyl ring and the rest of the variables are as defined in the specification. They are angiotensin II antagonists useful for treating hypertension, etc..