Imidazopyridazines. XV. Synthesis and Anxiolytic Activity of Some 3-(Benzamidomethyl and fluorobenzamidomethyl)-6-(fluoro, chloro and methylthio)-2-(4-tolyl and 3,4-methylenedioxyphenyl)imidazopyridazines
Syntheses are reported for some 3-(benzamido- and fluorobenzamido-methyl)-6-(fluoro, chloro and methylthio)-2-(4-methyl-, 4-t-butyl-, 4-cyclohexyl- and 3,4-methylenedioxy-phenyl)imidazopyridazines from the relevant 3-unsubstituted imidazopyr
Barlin, Gordon B.,Davies, Les P.,Glenn, Brok,Harrison, Peter W.,Ireland, Stephen J.
p. 609 - 622
(2007/10/02)
Synthesis of imidazo[1,2-b]pyridazines: Fenbendazole, oxifenbendazole analogs and related derivatives
A series of imidazo[1,2-b]pyridazines has been prepared and evaluated for macrofilaricidal activity against Brugia pahangi or Acanthocheilonema viteae infections in jirds. The imidazo[1,2-b]pyridazine analogs of fenbendazole and oxifenbendazole are report
Mourad,Wise,Townsend
p. 1365 - 1372
(2007/10/02)
Imidazopyridazines. XII. Syntheses and Central Nervous System Activities of Some Substituted Imidazopyridazines and Related Imidazopyridines, Imidazopyrimidines and Imidazopyrazines
Syntheses are reported for some 6-chloro(alkoxy, alkylthio and phenylthio)-3-benzamidomethyl-(acetamidomethyl and methoxy)-2-arylimidazopyridines and some corresponding imidazo-pyridazines, imidazopyrimidines and imidazopyrazines.IC50 values (or percentage displacement) are reported and discussed for the displacement of 3H>diazepam from rat brain membrane by each of these compounds.The imidazopyridines were generally less potent than the imidazopyridazines but considerably more potent than the corresponding imidazopyrimidines or imidazopyrazines.Substitution of 2-aryl group by a 2-alkyl group in imidazopyridazines led to a significant loss of activity.
Barlin, Gordon B.,Davies, Les P.,Ireland, Stephen J.,Ngu, Maria M. L.,Zhang, Jiankuo
p. 877 - 888
(2007/10/02)
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