Palladium-Catalyzed Enantioselective C-H Aminocarbonylation: Synthesis of Chiral Isoquinolinones
A Pd-catalyzed enantioselective C-H carbonylation by desymmetrization was developed with commercially available L-pyroglutamic acid as chiral ligand. Isoquinolinones were successfully obtained with good yields and high enantioselectivities. Mechanistic studies and DFT calculations provided a reasonable reaction pathway.
Diazaphospholene Precatalysts for Imine and Conjugate Reductions
The first examples of 1,3,2-diazaphospholene-catalyzed imine reduction and conjugate reduction reactions are reported. This approach employs readily synthesized alkoxydiazaphospholene precatalysts that can be handled in open air. Reduction of substrates containing Lewis basic functionality, isolated unsaturation, and protic functional groups was accomplished. The synthetic utility of this approach is demonstrated by the synthesis of the important antiparkinson medicine rasagiline and the natural product zingerone.
Adams, Matt R.,Tien, Chieh-Hung,Huchenski, Blake S. N.,Ferguson, Michael J.,Speed, Alexander W. H.
supporting information
p. 6268 - 6271
(2017/05/19)
Characterization of Z-blocked Isomeric Dipeptides by Fast Atom Bombardment Tandem Mass Spectrometry and Kinetic Energy Release Measurements
Fast- and slow-reacting, protonated, Z-blocked (Z = benzyloxycarbonyl) phenylalanylphenylalanine and alanylphenylalanyl diastereomeric dipeptides undergo decarboxylation through two competing pathways assisted by the migration of the urethane benzyl group
Mammoliti, Ezio,Sindona, Giovanni,Uccella, Nicola
p. 495 - 501
(2007/10/02)
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