Discovery of indenopyrazoles as a new class of hypoxia inducible factor (HIF)-1 inhibitors
The indenopyrazole framework was investigated as a new class of HIF-1α inhibitors. Indenopyrazole 2l was found to most strongly inhibit the hypoxia-induced HIF-1α transcriptional activity (IC50 = 0.014 μM) among all of the known compounds havin