The present invention relates to N-aryl pyrazole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators. In particular, the compounds of this invention include a compound of Formula (I).
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Page/Page column 84
(2018/07/05)
BIARYL PYRAZOLES AS NRF2 REGULATORS
The present invention relates to biaryl pyrazole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.
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Page/Page column 154
(2017/08/01)
NRF2 REGULATORS
Provided are aryl analogs,pharmaceutical compositions containing them and their use as NRF2 regulators.
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Page/Page column 325
(2017/01/02)
Electroreductive Deoxygenation of Methanesulfonates of α-Hydroxy Esters via a Catalytic Selenation-Deselenation Sequence
The methanesulfonates of α-hydroxy esters were converted to the corresponding deoxygenated esters in 70-88percent yields by the indirect electrolysis with diphenyl diselenide as a recyclable reagent in a divided cell.This deoxygenation method may involve the formation of α-phenylselenoester by replacement of α-methylsulfonyloxy group with phenylselenide anion followed by capture of the α-phenylseleno group with phenylselenide anion.
INTRAMOLECULAR PHOTOCYCLOADDITIONS ON DIOXOLENONES: AN EFFICIENT METHOD FOR THE SYNTHESIS OF MEDIUM-SIZED RINGS
The intramolecular photocycloaddition of dioxolenones to simple olefins leads to the formation of six-, seven-, and eight-membered rings in good yields.Asymmetric induction in the formation of cyclooctanes is described.
Winkler, Jeffrey D.,Hey, John P.,Hannon, Francis J.
p. 55 - 60
(2007/10/02)
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