Compounds are described of the formula STR1 wherein R1 represents a hydrogen atom, a hydroxyl group or a group selected from --OCOCH=CHCH(CH3)(CH2)3 CH3, --OCOCH=CHC(CH3)=CHCH(CH3/sub
-
(2008/06/13)
The Squalestatins: Novel Inhibitors of Squalene Synthase. Enzyme Inhibitory Activities and in Vivo Evaluation of C1-Modified Analogues
Squalestatin analogues modified in the C1 side chain were prepared and evaluated for their ability to inhibit rat liver microsomal and Candida squalene synthase (SQS) in vitro.While maintaining the 4,6-dimethyloctenoate or 4,6-dimethyloctanoate ester grou
Procopiou, Panayiotis A.,Bailey, Esme J.,Bamford, Mark J.,Craven, Andy P.,Dymock, Brian W.,et al.
p. 3274 - 3281
(2007/10/02)
Bridged cyclic ketal derivatives
These compounds inhibit the enzyme squalene synthase and/or are intermediates for the preparation of compounds which inhibit the enzyme squalene synthase. Compounds of the invention may be formulated for use in a variety of conditions where a lowering of
-
(2008/06/13)
More Articles about upstream products of 142505-92-8