142523-67-9

Basic information

• Product Name: 3,4-DICHLOROBENZYL IODIDE
• Synonyms: 3,4-DICHLOROBENZYL IODIDE;1,2-Dichloro-4-(iodomethyl)benzene
• CAS NO: 142523-67-9
• Molecular Formula: C₇H₅Cl₂I
• Molecular Weight: 286.93
• Mol File: 142523-67-9.mol

Chemical Properties

• Boiling Point: 287.1 °C at 760 mmHg
• Flash Point: 127.4 °C
• Appearance: /
• Density: 1.932 g/cm³
• Vapor Pressure: 0.00438mmHg at 25°C
• Refractive Index: 1.646
• CAS DataBase Reference: 3,4-DICHLOROBENZYL IODIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DICHLOROBENZYL IODIDE(142523-67-9)
• EPA Substance Registry System: 3,4-DICHLOROBENZYL IODIDE(142523-67-9)

Safety Data

• Hazardous Substances Data: 142523-67-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
3,4-Dichlorobenzyl iodide is used as an alkylating agent for the synthesis of biologically active compounds, contributing to the development of new pharmaceuticals.
Used in Agrochemical Research:
In agrochemical research, 3,4-dichlorobenzyl iodide is utilized as a reagent to introduce the 3,4-dichlorobenzyl group into molecules, aiding in the creation of new agrochemicals.
Used in Dye Manufacturing:
3,4-Dichlorobenzyl iodide is used as a key intermediate in the manufacturing process of dyes, playing a crucial role in the production of various colorants.
Used in Fine Chemicals Production:
3,4-DICHLOROBENZYL IODIDE is also employed in the production of fine chemicals, where its unique properties are leveraged to create specialty chemicals for specific applications.

InChI:InChI=1/C7H5Cl2I/c8-6-2-1-5(4-10)3-7(6)9/h1-3H,4H2

Upstream product

• 6287-38-3 3,4-dichlorobenzaldehyde 
• 1805-32-9 3,4-dichlorobenzyl alcohol 
• 102-47-6 3,4-Dichlorophenylmethyl chloride 

Downstream Products

• 99793-19-8 1,5-Bis-(4-chloro-phenyl)-3-(3,4-dichloro-benzylsulfanyl)-1H-[1,2,4]triazole 
• 13616-22-3 1,6-bis-(3,4-dichloro-benzylsulfanyl)-[1,4]dithiino[2,3-d;5,6-d']dipyridazine 

Relevant articles and documents

Conversion of Aryl Aldehydes to Benzyl Iodides and Diarylmethanes by H3PO3/I2

For the first time, H3PO3 was used as both the reducing reagent and the promotor in the reductive benzylation reactions with aryl aldehydes. By using a H3PO3/I2 combination, various aromatic aldehydes underwent iodination reactions and Friedel-Crafts type reactions with arenes via benzyl iodide intermediates, readily producing benzyl iodides and diarylmethanes in good yields. Intramolecular cyclization reactions also took place, giving the corresponding cyclic compounds. This new strategy features easy-handling, low-cost, and metal-free conditions.

Preparation method of benzyl iodide and derivatives thereof

The invention discloses a preparation method of benzyl iodide and derivatives thereof, which comprises the following steps: in a protective atmosphere, carrying out heating reaction on aryl aldehyde and iodine elementary substance in the presence of a solvent and phosphorous acid to obtain benzyl iodide and derivatives thereof. According to the method, cheap and green solid phosphorous acid is selected as a reduction reagent for reaction, elemental iodine is selected as an iodine source, the benzyl iodide and the derivatives thereof are efficiently prepared from the aryl aldehyde compounds which are simple and easy to obtain by a one-pot one-step method under mild conditions, and the method has the advantages of simplicity in operation, cheap and easily available reagents, environmental friendliness and the like; and the use of expensive silicon-hydrogen compounds and transition metal catalysts is avoided, and the yield can reach 94% at most, so that the method is beneficial to industrial production.

Preparation method of benzyl iodide and derivatives thereof

The invention discloses a preparation method of benzyl iodide and derivatives thereof. The preparation method comprises the following steps: under the reduction action of sodium borohydride, a benzylalcohol compound shown as a formula I reacts with elemental iodine to obtain benzyl iodide shown as a formula II and derivatives thereof; in the formula I and the formula II, R represents one or moresubstituents on a benzene ring and is selected from at least one of aryl, substituted or unsubstituted alkyl, halogen and nitro. The preparation method of benzyl iodide and derivatives thereof is scientific and reasonable, sodium borohydride which is mild in reactivity, low in price and easily available is used as a reducing agent, and elemental iodine is convenient and easily available; in addition, the preparation method has the characteristics of simplicity and convenience in operation, high synthesis yield, easiness in product purification, environmental friendliness and the like.