14259-58-6

Basic information

• Product Name: 5'-deoxy-5'-iodouridine
• Synonyms: 5'-deoxy-5'-iodouridine;Uridine, 5'-deoxy-5'-iodo-;1-((2R,3R,4S,5S)-3,4-dihydroxy-5-(iodomethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
• CAS NO: 14259-58-6
• Molecular Formula: C₉H₁₁IN₂O₅
• Molecular Weight: 354.09851
• Mol File: 14259-58-6.mol

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 2.118g/cm³
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 5'-deoxy-5'-iodouridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-deoxy-5'-iodouridine(14259-58-6)
• EPA Substance Registry System: 5'-deoxy-5'-iodouridine(14259-58-6)

Safety Data

• Hazardous Substances Data: 14259-58-6(Hazardous Substances Data)

Usage

Uses

Used in Research Applications:
5'-deoxy-5'-iodouridine is used as a research tool for studying nucleic acid structure and function, as well as in the development of new pharmaceuticals. The presence of the iodine atom can alter the chemical and physical properties of the nucleoside, potentially leading to changes in its biological activity.
Used in RNA Probe Applications:
5'-deoxy-5'-iodouridine is used as a probe to investigate the behavior of RNA in various biological processes. Studies have shown that it can be incorporated into RNA molecules, providing insights into RNA's role in cellular functions and interactions.

Upstream product

• 14671-65-9 5'-deoxy-5'-iodo-2',3'-O-isopropylideneuridine 
• 58-96-8 uridine 

Downstream Products

• 14365-63-0 5'-deoxyuridin-4'-ene 
• 1613589-22-2 5'-deoxy-5'-iodo-4'-fluoro-2',3'-di-O-benzoyluridine 
• 1613589-23-3 4'-fluoro-2',3'-di-O-benzoyluridine 
• 1613589-28-8 C₂₆H₃₁FN₃O₁₀P 
• 1365255-42-0 C₃₀H₂₃N₅O₉ 
• 690270-09-8 benzoic acid (2R,3S,4R,5R)-2-azido-3,4-dibenzoyloxy-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydrofuran-2-ylmethyl ester 
• 139419-02-6 4'-azido-2',3'-di-O-benzoyl-5'-deoxy-5'-iodouridine 

Relevant articles and documents

4'-HALOGEN CONTAINING NUCLEOTIDE AND NUCLEOSIDE THERAPEUTIC COMPOSITIONS AND USES RELATED THERETO

Disclosed are halogen containing nucleotide and nucleoside therapeutic compositions and uses related thereto. In certain embodiments, the disclosure relates to the treatment or prophylaxis of viral infections. Such viral infections can include tongaviridae, bunyaviridae, arenaviridae, coronaviridae, flaviviridae, picornaviridae, Eastern, Western, and Venezuelan Equine Encephalitis (EEE, WEE and VEE, respectively), Chikungunya fever (CHIK), Ebola, Influenza, RSV, and Zika virus infections.

4'-HALOGEN CONTAINING NUCLEOTIDE AND NUCLEOSIDE THERAPEUTIC COMPOSITIONS AND USES RELATED THERETO

Disclosed are halogen containing nucleotide and nucleoside therapeutic compositions and uses related thereto. In certain embodiments, the disclosure relates to the treatment or prophylaxis of viral infections. Such viral infections can include tongaviridae, bunyaviridae, arenaviridae, coronaviridae, flaviviridae, picornaviridae, Eastern, Western, and Venezuelan Equine Encephalitis (EEE, WEE and VEE, respectively), Chikungunya fever (CHIK), Ebola, Influenza, RSV, and Zika virus infections.

Azido nucleosides and nucleotide analogs

Disclosed herein are 4′-azido-substituted nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of 4′-azido-substituted nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a 4′-azido-substituted nucleoside, a nucleotide and/or an analog thereof. Examples of viral infections include a respiratory syncytial viral (RSV) and influenza infection.

SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF

Disclosed herein are nucleosides, nucleotides and nucleotide analogs, methods of synthesizing the same and methods of treating diseases and/or conditions such as a Picornavirus and/or Flaviviridae infection with one or more nucleosides, nucleotides and nucleotide analogs.

SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF

Disclosed herein are nucleosides, nucleotides and nucleotide analogs, methods of synthesizing the same and methods of treating diseases and/or conditions such as a Coronaviridae virus, a Togaviridae virus, a Hepeviridae virus and/or a Bunyaviridae virus infection with one or more nucleosides, nucleotides and nucleotide analogs.

SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF

Disclosed herein are nucleosides, nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a Filoviridae virus infection with one or more nucleosides and/or nucleotide analogs.

SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF

Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a HCV infection with one or more nucleotide analogs.

The design, synthesis, and antiviral activity of 4′-azidocytidine analogues against hepatitis C virus replication: The discovery of 4′-azidoarabinocytidine

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Anti-viral nucleosides

4-Amino-1-((2R,3S,4S,5R)-5-azido-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one (I:R1=R2=R3=R4=H) and prodrugs thereof are hepatitis C(HCV) polymerase inhibitors. Also disclosed are comp

PROCESSES FOR PREPARING 4’AZIDO NUCLEOSIDE DERIVATIVES

A process for the preparation of a 4’-azido-2’,3’,5’-triacyl-nucleoside compound (I;B=B1; R1 is R1aCO-and R2 is R2aCO-) or a 4’-azidonucleoside compounds (I; B is B1 or B2 and R1 and R2 are