Substituted N-phenyl sulfonamide compounds inhibit WDR5-MYC interactions, and the compounds and their pharmaceutical compositions are useful for treating disorders and conditions in a subject, such as cancer cell proliferation.
-
Paragraph 001293-001294
(2021/02/05)
Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction
The treatment of tumors driven by overexpression or amplification of MYC oncogenes remains a significant challenge in drug discovery. Here, we present a new strategy toward the inhibition of MYC via the disruption of the protein-protein interaction betwee
Macdonald, Jonathan D.,Chacón Simon, Selena,Han, Changho,Wang, Feng,Shaw, J. Grace,Howes, Jennifer E.,Sai, Jiqing,Yuh, Joannes P.,Camper, Demarco,Alicie, Bethany M.,Alvarado, Joseph,Nikhar, Sameer,Payne, William,Aho, Erin R.,Bauer, Joshua A.,Zhao, Bin,Phan, Jason,Thomas, Lance R.,Rossanese, Olivia W.,Tansey, William P.,Waterson, Alex G.,Stauffer, Shaun R.,Fesik, Stephen W.
p. 11232 - 11259
(2019/12/25)
Five sulfur hexafluoride substituted benzo-type compounds and use thereof
The invention discloses a sulfur pentafluoride-substituted benzopyran compound shown in the structural formula I or its pharmaceutically acceptable salt or stereoisomer or prodrug molecule. The sulfur pentafluoride-substituted benzopyran compound has effe
-
Paragraph 0118; 0128; 0129
(2018/10/11)
Pentafluorosulfanyl-Substituted Benzopyran Analogues As New Cyclooxygenase-2 Inhibitors with Excellent Pharmacokinetics and Efficacy in Blocking Inflammation
In this report, we disclose the design and synthesis of a series of pentafluorosulfanyl (SF5) benzopyran derivatives as novel COX-2 inhibitors with improved pharmacokinetic and pharmacodynamic properties. The pentafluorosulfanyl compounds showe
Zhang, Yanmei,Wang, Yican,He, Chuang,Liu, Xiaorong,Lu, Yongzhi,Chen, Tingting,Pan, Qiong,Xiong, Jingfang,She, Miaoqin,Tu, Zhengchao,Qin, Xiaochu,Li, Minke,Tortorella, Micky D.,Talley, John J.
p. 4135 - 4146
(2017/06/05)
More Articles about upstream products of 1426290-12-1