Inhibitors of acyl-CoA:Cholesterol O-acyltransferase. 17. Structure-activity relationships of several series of compounds derived from N-chlorosulfonyl isocyanate
Several series of acyl-CoA:cholesterol O-acyltransferase inhibitors were prepared by the stepwise addition of nitrogen, oxygen, and sulfur nucleophiles to N-chlorosulfonyl isocyanate. The (aminosulfonyl)ureas 3-44 were the most potent inhibitors in vitro,
Picard, Joseph A.,O'Brien, Patrick M.,Sliskovic, Drago R.,Anderson, Maureen K.,Bousley, Richard F.,Hamelehle, Katherine L.,Krause, Brian R.,Stanfield, Richard L.
p. 1243 - 1252
(2007/10/03)
Inhibitors of acyl-coA:cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity [2]
The present invention is directed to compounds of the following general Formula I, methods for using the compounds of Formula I, pharmaceutical compositions thereof, and processes for preparing the compounds. STR1 wherein X is oxygen or sulfur; wherein R
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(2008/06/13)
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