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142644-39-1

N(3)-methyl-3'-azido-3'-deoxythymidine 5'-triphosphate is a nucleoside analog and a derivative of the antiretroviral medication zidovudine (AZT). It is a triphosphate compound containing three phosphate groups, which is crucial for its antiviral activity. N(3)-methyl-3'-azido-3'-deoxythymidine 5'-triphosphate mimics the structure of thymidine and inhibits the reverse transcriptase enzyme necessary for HIV replication, thereby interfering with viral DNA synthesis and blocking the virus from multiplying. The presence of the azido group enhances its affinity for the viral DNA polymerase, increasing its potency and making it an effective agent against HIV replication.

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  • Thymidine5'-(tetrahydrogen triphosphate), 3'-azido-3'-deoxy-3-methyl- (9CI)

    Cas No: 142644-39-1

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  • 142644-39-1 Structure

  • Basic information

    1. Product Name: N(3)-methyl-3'-azido-3'-deoxythymidine 5'-triphosphate
    2. Synonyms: N(3)-methyl-3'-azido-3'-deoxythymidine 5'-triphosphate
    3. CAS NO:142644-39-1
    4. Molecular Formula: C11H18N5O13P3
    5. Molecular Weight: 521.207603
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 142644-39-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: °Cat760mmHg
    3. Flash Point: °C
    4. Appearance: /
    5. Density: g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N(3)-methyl-3'-azido-3'-deoxythymidine 5'-triphosphate(CAS DataBase Reference)
    10. NIST Chemistry Reference: N(3)-methyl-3'-azido-3'-deoxythymidine 5'-triphosphate(142644-39-1)
    11. EPA Substance Registry System: N(3)-methyl-3'-azido-3'-deoxythymidine 5'-triphosphate(142644-39-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 142644-39-1(Hazardous Substances Data)

142644-39-1 Usage

Uses

Used in Pharmaceutical Industry:
N(3)-methyl-3'-azido-3'-deoxythymidine 5'-triphosphate is used as an antiviral agent for the treatment of HIV and AIDS. Its ability to inhibit the reverse transcriptase enzyme and interfere with viral DNA synthesis makes it a potent weapon against the replication of the HIV virus.
Used in Research Applications:
In addition to its clinical use, N(3)-methyl-3'-azido-3'-deoxythymidine 5'-triphosphate can be utilized in research settings to study the mechanisms of HIV replication and the development of resistance to antiretroviral medications. Its unique structure and activity also make it a valuable tool for investigating the interactions between nucleoside analogs and viral enzymes, contributing to the advancement of antiviral drug discovery and development.

Check Digit Verification of cas no

The CAS Registry Mumber 142644-39-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,2,6,4 and 4 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 142644-39:
(8*1)+(7*4)+(6*2)+(5*6)+(4*4)+(3*4)+(2*3)+(1*9)=121
121 % 10 = 1
So 142644-39-1 is a valid CAS Registry Number.

142644-39-1Downstream Products

142644-39-1Relevant articles and documents

Synthesis and anti-human immunodeficiency virus type 1 (HIV-1) activity of 3-substituted derivatives of 3'-azido-3'-deoxythymidine (AZT), and inhibition of HIV-1 reverse transcriptase by their 5'-triphosphates

Kitade,Suzuki,Hirota,Maki,Nakane,Ono,Baba,Shigeta

, p. 920 - 924 (1992)

Various 3-substituted 3'-azido-3'-deoxythymidine analogs (2a-i) were prepared by the reaction of 3'azido-3'-deoxythymidine (1), AZT with N,N-dimethylformamide dialkylacetal or alkyl bromide in the presence of base and their activities against human-immuno

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