- Synthesis of a preclavulones analogous: (±) 8,12-trans-(5Z,14Z)-9-oxo-prosta-5,10,14-trienoic acid methyl ester via its 10-11 dihydroprecursor from allyl 2-oxo-cyclopentanecarboxylate
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In this paper we report a method to prepare the (±)-8,12-trans(5Z,14Z)-9-oxo-prosta-5,10,14-trienoic acid methyl ester 1, a 11-desoxyprostanoid correlated to the class of Preclavulones, via a new easy synthesis of its 10-11 dihydroprecursor 16 and through a general procedure for the conversion of these 10-11 dihydrocompounds to the unsaturated analogous derivatives.
- Leggeri,Di Giacomo,Papeo,Pirillo,Traverso
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p. 117 - 126
(2007/10/02)
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- Synthesis of a 11-deoxyprostanoid in the area of Preclavulones: (±)- 8,12-trans-(5Z-14Z)-9-oxo-prosta-5,14-dienoic acid from 2-allyl-2- cyclopenten-1-one
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Following our research on the arachidonic acid metabolites and their derivatives with potential biological activity, we describe the synthesis of the (±-8,12-trans-(5Z, 14Z)-9-oxo-prosta-5,14-dienoic acid, a 11- deoxyprostanoid correlated to the class of Preclavulones, one of the unusual families of marine eicosanoids from the coral Clavularia Viridis with considerable biological interest.
- Di Giacomo,Leggeri,Papeo,Pirillo,Traverso
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p. 379 - 385
(2007/10/02)
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