- α-Difluoromethylation on sp3 Carbon of Nitriles Using Fluoroform and Ruppert-Prakash Reagent
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Difluoromethylation on sp3 carbon of various nitrile compounds with lithium base and fluoroform (CF3H), which is an ideal difluoromethylating reagent, is shown to provide the α-difluoromethylated nitrile products with an all-carbon q
- Aikawa, Kohsuke,Maruyama, Kenichi,Honda, Kazuya,Mikami, Koichi
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- Use of fluoroform as a source of difluorocarbene in the synthesis of N-CF2H heterocycles and difluoromethoxypyridines
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Fluoroform is used as a source of difluorocarbene to convert various N-, O-, and C-nucleophiles to their difluoromethylated derivatives. Imidazole, benzimidazole, benztriazole, hydroxypyridines, and their derivatives underwent reaction at moderate temperatures and atmospheric pressure, using potassium hydroxide as base in a two-phase (water/acetonitrile) process to provide moderate to good yields of the respective products. Nitrophenols required addition of a co-solvent (methanol) to obtain good yields of products.
- Thomoson, Charles S.,Wang, Linhua,Dolbier, William R.
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- Difluoromethylation of some C-H acids with chlorodifluoromethane under conditions of phase transfer catalysis (PTC)
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Selected C-H acids react with difluorocarbene generated from chlorodifluoromethane with concentrated aqueous solution of sodium hydroxide, and a catalyst, benzyltriethylammonium chloride (TEBAC) in benzene or THF affording C-difluoromethyl substituted der
- Nawrot, Ewelina,Jończyk, Andrzej
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experimental part
p. 466 - 469
(2009/12/05)
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