142741-24-0Relevant articles and documents
Biologically active indole and bisindole alkaloids from Tabernaemontana divaricata
Kam, Toh-Seok,Pang, Huey-Shen,Lim, Tuck-Meng
, p. 1292 - 1297 (2003)
The ethanol extract of the leaves of Tabernaemontana divaricata (double flower variety) provided a total of 23 alkaloids, including the new aspidosperma alkaloids, taberhanine, voafinine, N-methylvoafinine, voafinidine, voalenine and the new bisindole alkaloid, conophylinine in addition to the previously known, biologically active bisindole, conophylline and its congener, confoline. The structures of the new alkaloids were established by spectroscopic methods. The preparation and characterization of the corresponding quinones of the biologically active bisindoles are also described in relation to a structure-activity study of these compounds with respect to their action in stimulating insulin expression.
Total synthesis of (-)-conophylline and (-)-conophyllidine
Han-Ya, Yuki,Tokuyama, Hidetoshi,Fukuyama, Tohru
supporting information; experimental part, p. 4884 - 4887 (2011/06/26)
Double take: The total syntheses of the title compounds were accomplished in a highly convergent manner. The approach features the regio- and diastereoselective Polonovski-Potier-type reaction for the coupling of two aspidosperma skeletons and the formation of the dihydrofuran ring. Troc=2,2,2-trichloroethoxycarbonyl. Copyright