The synthesis of substituted pyridylpyrimidine fungicides using palladium-catalysed cross-coupling reactions
Various substituted phenyl, pyridyl and benzyl zinc chlorides have been generated from the corresponding lithium or magnesium organometallic reagents. These have been cross-coupled with 2-(6-bromo-2- pyridyl)pyrimidines in the presence of tetrakis(triphenylphosphine)palladium(0) to produce a series of substituted pyridylpyrimidine fungicides in 32-99% yields. (C) 2000 Elsevier Science Ltd.
Hargreaves, Stephanie L.,Pilkington, Brian L.,Russell, Sally E.,Worthington, Paul A.
Fungicidal compounds having the formula (I): STR1 wherein R1 is an optionally substituted phenyl group, C3-6 cycloalkyl optionally substituted by alkyl or alkyl; R2, R3, R4, R5, R6/su
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(2008/06/13)
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