Enzymatic resolution of 1,2-diols: Preparation of optically pure dropropizine
Kinetic resolution of (R,S)-3-(4-phenyl-1-piperazinyl)-1,2-propranediol diacetate (2) by alcoholysis with n-propanol was carried out under lipase Amano PS catalysis in various organic solvents. Pure enantiomers of the corresponding diol (1) are useful as antitussive and central sedative therapeutic agents.
Bianchi,Bosetti,Cesti,Golini
p. 3231 - 3234
(2007/10/02)
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