Directing group enhanced carbonylative ring expansions of amino-substituted cyclopropanes: Rhodium-catalyzed multicomponent synthesis of N-heterobicyclic enones
Aminocyclopropanes equipped with suitable N-directing groups undergo efficient and regioselective Rh-catalyzed carbonylative C-C bond activation. Trapping of the resultant metallacycles with tethered alkynes provides an atom-economic entry to diverse N-heterobicyclic enones. These studies provide a blueprint for myriad N-heterocyclic methodologies.
Shaw, Megan H.,Melikhova, Ekaterina Y.,Kloer, Daniel P.,Whittingham, William G.,Bower, John F.
p. 4992 - 4995
(2013/05/22)
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