1428229-05-3Relevant articles and documents
Discovery of biological evaluation of pyrazole/imidazole amides as mGlu5 receptor negative allosteric modulators
Chae, Eunhee,Shin, Yong-Je,Ryu, Eun-Ju,Ji, Mi Kyung,Ryune Cho, Nahm,Lee, Ki-Ho,Jeong, Hyun Ji,Kim, Soo-Jin,Choi, Yeonjung,Seok Oh, Kyung,Park, Chun-Eung,Soo Yoon, Young
, p. 2134 - 2139 (2013/05/09)
Development of SAR in a 5-aryl-3-acylpyridinyl-pyrazoles and 1-aryl-4-acylpyridinyl imidazoles series of mGlu5 receptor negative allosteric modulators (mGluR5 NAMs) using a functional cell-based assay is described in this Letter. Analysis of the Ligand-lipophilic efficiency (LipE) of compounds provided new insight for the design of potent mGluR5 negative allosteric modulators with anti-depressant activities.