- Discovery of Benzofuran Derivatives that Collaborate with Insulin-Like Growth Factor 1 (IGF-1) to Promote Neuroprotection
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A series of benzofuran derivatives with neuroprotective activity in collaboration with IGF-1 was discovered using a newly developed cell-based assay involving primary neural cells prepared from rat hippocampal and cerebral cortical tissues. A structure-ac
- Wakabayashi, Takeshi,Tokunaga, Norihito,Tokumaru, Kazuyuki,Ohra, Taiichi,Koyama, Nobuyuki,Hayashi, Satoru,Yamada, Ryuji,Shirasaki, Mikio,Inui, Yoshitaka,Tsukamoto, Tetsuya
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p. 5109 - 5114
(2016/06/13)
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- Benzofuran derivatives
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The present invention provides a compound represented by the following formula (I): wherein: Ring A represents an optionally substituted piperazine ring, an optionally substituted morpholine ring, or an optionally substituted homopiperazine ring;R1 and R2 are the same or different from each other, and represent a hydrogen atom or optionally substituted lower alkyl;R3 and R4 are the same or different from each other, and represent a hydrogen atom or halogenated or non-halogenated lower alkyl;R5 to R7 are the same or different from each other, and represent a hydrogen atom, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkoxy, optionally substituted cycloalkyl, optionally substituted aryl, an optionally substituted aromatic heterocyclic ring, optionally substituted amino, or acyl; and represents a single bond or double bond, or a salt thereof.
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Page/Page column 58
(2010/09/18)
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- 2,2,4,6,7-Pentamethyl-2,3-dihydrobenzofuran-5-methyl (Pbfm) as an alternative to the trityl group for the side-chain protection of cysteine and asparagine/glutamine
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The benzyl derivative of the Pbf group, which is the most commonly used side-chain protecting group for Arg, has been proposed for the protection of the side chains of Cys, Asp, and Glu. In the three cases, the new protecting group (Pbfm) was removed with a high concentration of TFA during the cleavage and global deprotection step. In addition, the Pbfm group can be removed from the Cys residue by using very dilute TFA solutions. Furthermore, when Cys is protected with the Pbfm group, it can be removed by oxidative treatment, thereby directly rendering the disulfide bridge on the solid phase.
- Garcia, Oscar,Bofill, Josep M.,Nicolas, Ernesto,Albericio, Fernando
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experimental part
p. 3631 - 3640
(2010/08/22)
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- Herbicidal cyclohexane-1,3-dione derivatives and their preparation process
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The present invention relates to novel cyclohexane-1,3-dione derivatives of formula (I) useful as herbicides and plant-growth regulants. STR1 wherein, X is selected from the group consisting of hydrogen, C1 -C6 alkyl, C2 -
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- UNEXPECTED IODINE CATALYZED CYCLIZATION FOR SYNTHESIS OF 2,2-DIALKYL-2,3-DIHYDROBENZOFURANS
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2-(β-Methylallyl)phenol and 2-isobutenylphenol derivatives were easily cyclized to 2,2-dimethyl-2,3-dihydrobenzofurans in the presence of a catalytic amount of iodine without any formation of iodinated products.
- Kim, Kyoung Mahn,Ryu, Eung K.
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p. 219 - 224
(2007/10/02)
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- ONE-POT SYNTHESES OF 2,3-DIHYDRO-2,2-DIMETHYLBENZOFURAN DERIVATIVES
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A tandem Claisen rearrangement-cyclization reaction of aryl methallyl ethers afforded the corresponding 2,3-dihydro-2,2-dimethylbenzofuran derivatives at -70 deg C with aluminium chloride.
- Kim, Kyoung Mahn,Kim, Hyoung Rae,Ryu, Eung K.
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p. 497 - 505
(2007/10/02)
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- The 2,2,4,6,7-Pentamethyldihydrobenzofuran-5-sulfonyl Group (Pbf) as Arginine Side Chain Protectant
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The 2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl residue (Pbf) is more easily deblocked by trifluoroacetic acid (TFA) than the corresponding Pmc analog and can be used efficiently in the synthesis of arginine-containing peptides.
- Carpino, Louis A.,Shroff, Hitesh,Triolo, Salvatore A.,Mansour, El-Sayed M. E.,Wenschuh, Holger,Albericio, Fernando
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p. 7829 - 7832
(2007/10/02)
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