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CAS

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1428775-91-0

(3R,4R)-tert-butyl 3-(hydroxymethyl)-4-methoxypyrrolidine-1-carboxylate is a complex organic compound featuring a pyrrolidine ring with a tert-butyl group, a hydroxymethyl group, a methoxy group, and a carboxylate functional group. As a pyrrolidine derivative, it holds potential in the pharmaceutical industry for the development of innovative drugs, leveraging its distinctive structural and functional attributes.
Used in Pharmaceutical Industry:
(3R,4R)-tert-butyl 3-(hydroxymethyl)-4-methoxypyrrolidine-1-carboxylate is used as a precursor in the synthesis of new pharmaceutical compounds due to its unique structure and functional groups that can be further modified or utilized in drug design for various therapeutic applications.
Further research and testing are required to fully explore the potential uses and properties of this compound, as its complex structure and functional groups may offer novel avenues for drug development and therapeutic interventions.

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  • (3R,4R)-tert-butyl 3-(hydroxymethyl)-4-methoxypyrrolidine-1-carboxylate

    Cas No: 1428775-91-0

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  • 1428775-91-0 Structure

  • Basic information

    1. Product Name: (3R,4R)-tert-butyl 3-(hydroxymethyl)-4-methoxypyrrolidine-1-carboxylate
    2. Synonyms: (3R,4R)-tert-butyl 3-(hydroxymethyl)-4-methoxypyrrolidine-1-carboxylate;tert-butyl(3R,4R)-3-(hydroxymethyl)-4-methoxypyrrolidine-1-carboxylate;rel-tert-butyl (3R,4R)-3-(hydroxymethyl)-4-methoxypyrrolidine-1-carboxylate;EOS-60658
    3. CAS NO:1428775-91-0
    4. Molecular Formula: C11H21NO4
    5. Molecular Weight: 231.28874
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1428775-91-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (3R,4R)-tert-butyl 3-(hydroxymethyl)-4-methoxypyrrolidine-1-carboxylate(CAS DataBase Reference)
    10. NIST Chemistry Reference: (3R,4R)-tert-butyl 3-(hydroxymethyl)-4-methoxypyrrolidine-1-carboxylate(1428775-91-0)
    11. EPA Substance Registry System: (3R,4R)-tert-butyl 3-(hydroxymethyl)-4-methoxypyrrolidine-1-carboxylate(1428775-91-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1428775-91-0(Hazardous Substances Data)

1428775-91-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1428775-91-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,8,7,7 and 5 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1428775-91:
(9*1)+(8*4)+(7*2)+(6*8)+(5*7)+(4*7)+(3*5)+(2*9)+(1*1)=200
200 % 10 = 0
So 1428775-91-0 is a valid CAS Registry Number.

1428775-91-0Relevant articles and documents

Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants

Cheng, Hengmiao,Nair, Sajiv K.,Murray, Brion W.,Almaden, Chau,Bailey, Simon,Baxi, Sangita,Behenna, Doug,Cho-Schultz, Sujin,Dalvie, Deepak,Dinh, Dac M.,Edwards, Martin P.,Feng, Jun Li,Ferre, Rose Ann,Gajiwala, Ketan S.,Hemkens, Michelle D.,Jackson-Fisher, Amy,Jalaie, Mehran,Johnson, Ted O.,Kania, Robert S.,Kephart, Susan,Lafontaine, Jennifer,Lunney, Beth,Liu, Kevin K.-C.,Liu, Zhengyu,Matthews, Jean,Nagata, Asako,Niessen, Sherry,Ornelas, Martha A.,Orr, Suvi T. M.,Pairish, Mason,Planken, Simon,Ren, Shijian,Richter, Daniel,Ryan, Kevin,Sach, Neal,Shen, Hong,Smeal, Tod,Solowiej, Jim,Sutton, Scott,Tran, Khanh,Tseng, Elaine,Vernier, William,Walls, Marlena,Wang, Shuiwang,Weinrich, Scott L.,Xin, Shuibo,Xu, Haiwei,Yin, Min-Jean,Zientek, Michael,Zhou, Ru,Kath, John C.

, p. 2005 - 2024 (2016/03/22)

First generation EGFR TKIs (gefitinib, erlotinib) provide significant clinical benefit for NSCLC cancer patients with oncogenic EGFR mutations. Ultimately, these patients' disease progresses, often driven by a second-site mutation in the EGFR kinase domain (T790M). Another liability of the first generation drugs is severe adverse events driven by inhibition of WT EGFR. As such, our goal was to develop a highly potent irreversible inhibitor with the largest selectivity ratio between the drug-resistant double mutants (L858R/T790M, Del/T790M) and WT EGFR. A unique approach to develop covalent inhibitors, optimization of reversible binding affinity, served as a cornerstone of this effort. PF-06459988 was discovered as a novel, third generation irreversible inhibitor, which demonstrates (i) high potency and specificity to the T790M-containing double mutant EGFRs, (ii) minimal intrinsic chemical reactivity of the electrophilic warhead, (iii) greatly reduced proteome reactivity relative to earlier irreversible EGFR inhibitors, and (iv) minimal activity against WT EGFR.

PYRROLOPYRIMIDINE AND PURINE DERIVATIVES

-

, (2013/04/10)

The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Q, T, V, W, X, Y, Z, ring A, R1, R2, R3, R4, R5, R5a, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17 and m are defined herein. There novel pyrrolopyrimidine and purine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.

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