Atropisomeric flavoenzyme models with a modified pyrimidine ring: Syntheses, physical properties, and stereochemistry, in the reactions with NAD(P)H analogs
Optically active 5-deazaflavin derivatives (3-aryl-10-(4-tert-butylphenyl)pyrimido[4,5-b]quinoline-2,4(3H,10H)-di one) with an axial chirality at the pyrimidine ring have been synthesized, and the kinetics of enantiomerization have been measured for some
Ohno,Kunitomo,Kawai,Kawamoto,Tomishima,Yoneda
p. 9344 - 9355
(2007/10/03)
Synthesis and reaction of novel 5-deazaflavins with axial chirality at pyrimidine ring moiety
A series of novel 5-deazaflavin derivatives possessing axial chirality at pyrimidine ring moiety have been prepared to investigate effects of the pyrimidine site on the stereoselective reactions between flavins and substrates. Successful optical resolutio