- INHIBITORS OF HEPATITIS C VIRUS POLYMERASE
-
The present invention provides, among other things, compounds represented by the general Formula I: (I) and pharmaceutically acceptable salts thereof, wherein L and A (and further substituents) are as defined in classes and subclasses herein and compositions (e.g., pharmaceutical compositions) comprising such compounds, which compounds are useful as inhibitors of hepatitis C virus polymerase, and thus are useful, for example, as medicaments for the treatment of HCV infection.
- -
-
Paragraph 331; 332
(2016/10/11)
-
- POLYOL ETHERS AND PROCESS FOR MAKING THEM
-
New polyol ether compounds and a process for their preparation. The process comprises reacting a polyol, a carbonyl compound, and hydrogen in the presence of hydrogenation catalyst, to provide the polyol ether. The molar ratio of polyol to carbonyl compound in the process is greater than 5:1.
- -
-
Page/Page column 7
(2010/03/31)
-
- HETEROCYCLIC AMINE CATALYST COMPOSITIONS FOR THE ALKOXYLATION OF ALCOHOLS TO GLYCOL ETHERS
-
Glycol ethers are made by a process in which an alcohol, an alkylene oxide and a catalytic amount of an aromatic, heterocyclic amine catalyst are contacted under reactive conditions. Representative catalysis include substituted and unsubsiituted pyridines and imidazoles. The process uses known oxides and alcohols, and produces more mono- and di- adduct products than does a corresponding process using a caustic catalyst. Moreover, the process can be conducted at a lower reaction temperature than a corresponding process using a caustic catalyst without sacrificing oxide conversion rates yet producing fewer carfoony! impurities.
- -
-
Page/Page column 8-9, 11
(2009/12/05)
-
- Combinatorial synthesis of PEG oligomer libraries
-
A simple chain-extending approach was established for the scale-up of the monoprotected monodisperse PEG diol materials. Reactions of THP-(OCH2CH2)n—OMs (n=4, 8, 12) with a large excess of commercially available H—(OCH2CH2)n—OH (n=1-4) under basic conditions led to THP-(OCH2CH2)n—OH (n=5-15). Similarly, Me-(OCH2CH2)n—OH (n=4-11, 13) were prepared from Me-(OCH2CH2)n—OMs (n=3, 7, 11). For the chain elongation steps, 40-80% yields were achieved through extraction purification. PEG oligomer libraries I and II were generated in 50-95% overall yields by alkylation or acylation of THP-(OCH2CH2)n—OH (n=1-15) followed by deprotection. Alkylation of Me-(OCH2CH2)n—OH (n=1-11, 13) with X—(CH2)m—CO2R (X=Br or OMs) and subsequent hydrolysis led to PEG oligomer library III in 30-60% overall yields. Combinatorial purification techniques were adapted to the larger-scale library synthesis. A total of 498 compounds, each with a weight of 2-5 g and a minimum purity of 90%, were synthesized.
- -
-
Page/Page column 9
(2010/02/15)
-
- METHOD FOR PRODUCING MONOALKYLENE GLYCOL MONOETHER
-
The invention relates to a method for producing monoalkylene glycol monoether of general formulas (Ia) and (Ib), wherein a group R is hydrogen, a methyl-, ethyl-, propyl- or butyl group and R1 is a phenyl or a linear or branched C1-C10 alkyl group consisting in reacting an alcohol R1OH (II) with an alkylene oxide (III) in the presence of a heterogeneous catalyst in a liquid phase which contains in the form of a catalytically active agent at least one composition of formula (IV): M1pAnm x zH2O, wherein M1is hydrogen and/or one or several cations of IA, IIA, IIIA groups, a IVA, IB, IIB, IIIB, IVB, VB, VIB, VIIB or VIIIB lanthanide groups, An is an anion of formula [M2qOn(OH)2(3-n)], wherein M2 is at least one cationic element from a group of pnicogens As, Sb and Bi, the index q is a value equal to 1, the index n is a fractional or an integer number equal to or greater than 0 and strictly less than 3, z is equal to 0 or an integer or fractional number strictly greater than 0 and equal or less than 10, the index p is a value normalised to 1 and the index m is a number ranging from 1.2 to 8 stoichiometrically obtainable from the electric charge of one or several cations M1 and from the electric charge of an An anion taking in to account the index p whose value is normalised to 1 at a temperature ranging from a room temperature to 350 °C, at a pressure ranging from atmospheric pressure to 80 bar and at a molar ratio alcohol II/alkylene oxide III ranging from 3:1 to 15:1.
- -
-
Page/Page column 24-25
(2010/02/14)
-
- Process for preventing consolidation of p-dichlorobenzene
-
A triethylene glycol derivative is added to p-dichlorobenzene so as to prevent consolidation and improve flowability of p-dichlorobenzene.
- -
-
-
