- Synthesis of novel derivatives of murrayafoline a and their inhibitory effect on LPS-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells
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A series of N-substituted-1,2,3-triazole murrayafoline A derivatives were successfully synthesized using click azide-alkyne Huisgen cycloaddition reaction between 1-methoxy-3-methyl-9-(3-azido)-propyl-9H-carbazole and substituted alkynes. Their chemical structures were confirmed by 1H, 13C NMR and HR-ESI-MS spectral data. In addition, the interested effects on LPS-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells of synthetic murrayafoline A derivatives were also investigated. Our results indicated that murrayafoline A derivatives containing 1,2,3-triazole nucleus potentially possessed anti-inflammatory action through inhibiting production of IL-6, IL-12 p40 and TNF-α.
- Thuy, Tran Thi Thu,Cuong, Nguyen Manh,Toan, Tran Quoc,Thang, Ngo Ngoc,Tai, Bui Huu,Nhiem, Nguyen Xuan,Hong, Hye-Jin,Kim, Sohyun,Legoupy, Stephanie,Koh, Young Sang,Kim, Young Ho
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p. 832 - 839
(2013/07/26)
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