- Discovery of a Potent and Orally Efficacious TGR5 Receptor Agonist
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TGR5 is a G protein-coupled receptor (GPCR), activation of which promotes secretion of glucagon-like peptide-1 (GLP-1) and modulates insulin secretion. The 2-thio-imidazole derivative 6g was identified as a novel, potent, and selective TGR5 agonist (hTGR5
- Agarwal, Sameer,Patil, Amit,Aware, Umesh,Deshmukh, Prashant,Darji, Brijesh,Sasane, Santosh,Sairam, Kalapatapu V. V. M.,Priyadarsiny, Priyanka,Giri, Poonam,Patel, Harilal,Giri, Suresh,Jain, Mukul,Desai, Ranjit C.
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- 2-THIO-IMIDAZOLE DERIVATIVES AS TGR5 MODULATORS
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The present invention relates to compounds of the general Formula I their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, enantiomers, diastereomers, prodrugs, their N-oxide, metabolites, polymorphs, use of these compounds in medicine for treating diabetes (TGR5 modulators) and the intermediates involved in their preparation.
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Page/Page column 25; 33
(2013/04/25)
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