143059-69-2

Basic information

• Product Name: cefaclor iMpurity C
• Synonyms: cefaclor iMpurity C
• CAS NO: 143059-69-2
• Molecular Formula: C₁₅H₁₄ClN₃O₄S
• Molecular Weight: 367.80736
• Mol File: 143059-69-2.mol

Chemical Properties

• Boiling Point: 713.4±60.0 °C(Predicted)
• Appearance: /
• Density: 1.62±0.1 g/cm3(Predicted)
• PKA: 1.95±0.50(Predicted)
• CAS DataBase Reference: cefaclor iMpurity C(CAS DataBase Reference)
• NIST Chemistry Reference: cefaclor iMpurity C(143059-69-2)
• EPA Substance Registry System: cefaclor iMpurity C(143059-69-2)

Safety Data

• Hazardous Substances Data: 143059-69-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Quality Control:
Cefaclor Impurity C is used as a target for monitoring and controlling impurities in cefaclor pharmaceutical formulations. It is quantified and controlled through analytical methods such as high-performance liquid chromatography (HPLC) to ensure the safety and efficacy of the drug.
In the pharmaceutical industry, maintaining the quality and purity of drugs is of utmost importance. Cefaclor Impurity C serves as a critical parameter in the quality control processes of cefaclor formulations. By accurately measuring and controlling the levels of this impurity, pharmaceutical companies can ensure that the final drug product meets the required safety and efficacy standards, ultimately benefiting patients who rely on these medications for treatment.

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Relevant articles and documents

Cefaclor preparation and preparation method thereof

The invention discloses a cefaclor preparation and a preparation method thereof. The preparation method comprises: preparing cefaclor crystal, pretreating a main material and auxiliary materials, weighing, mixing, forming, and packaging; wherein the preparation of the cefaclor crystal includes subjecting 7-ACCA and potassium (R)-[(3-ethoxy-1-methyl-3-oxoprop-1-enyl)amino]phenylacetate to silylation, acylation, condensation, acid hydrolysis, extraction and cleaning, decoloring, and crystallization; the preparation comprises the cefaclor crystal as the main material and auxiliary materials, the cefaclor crystal is /=33 degrees in angle of repose, 0.50-0.60 g/m in bulk density, 0.70-0.80 g/ml in compactness and 40-60 Mum in D10 of particle size distribution, 120-140 Mum in D50 and 210-230 Mum in D90. The conversion rate of cefaclor in chemical synthesis is increased, reaction conditions are simplified, the crystal form and particle size distribution of the cefaclor crystal are improved, and the quality of finished cefaclor crystal is improved.

Penicillin acylase in the industrial production of β-lactam antibiotics

Immobilized penicillin acylase is a biocatalyst suitable for the kinetically controlled industrial synthesis of semi-synthetic antibiotics in aqueous environments. Amoxiciliin and ampicillin are obtained by condensing 6-aminopenicillanic acid with the amide or ester of D-( - )-4-hydroxyphenyIglycine and D-( - )phenylglycine, respectively. Similarly, the cephalosporin antibiotics cefadroxil and cephalexin can be obtained from 7-aminodesacetoxycephalosporanic acid.

Process for the preparation of 3-chloro-cefem compounds

The process comprises a series of stages essentially comprising the protection of the functional groups of the side chain of Ampicillin, esterification of the acid group, oxidation to sulphoxide, expansion of the thiazole ring to a thiazine ring, ozonolysis of the exomethylene cefam derivative obtained, substitution of the hydroxyl group by chlorine and de-protection of the functional groups, in which the order of some stages can be varied without affecting the final result.