Cyclic RGD Peptide Analogues as Antiplatelet Antithrombotics
Stimulation of platelets activates GPIIbIIIa, the heterodimeric integrin receptor, to bind fibrinogen (Fg), which results in platelet aggregation.GPIIbIIIa/Fg binding inhibitors are potentially suitable for acute use during and after thrombolytic therapy
Barker, Peter L.,Bullens, Sherron,Bunting, Stuart,Burdick, Daniel J.,Chan, Kathryn S.,et al.
p. 2040 - 2048
(2007/10/02)
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