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1431291-44-9

Mal-amido-PEG2-TFP ester is a PEG (polyethylene glycol) linker that contains a maleimide and TFP (trifluorophenyl) ester end group. Mal-amido-PEG2-TFP ester is designed to enhance the solubility and reactivity of molecules in aqueous media. The maleimide group is reactive with thiols within a pH range of 6.5 to 7.5, while the TFP ester can react with primary amine groups and is less prone to hydrolysis compared to NHS ester. The hydrophilic PEG chains contribute to the increased water solubility of the compound, with longer PEG chains providing better solubility than shorter ones.

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  • 2,3,5,6-tetrafluorophenyl 3-(2-{2-[3-(2,5-dioxopyrrol-1-yl)propanamido]ethoxy}ethoxy)propanoate

    Cas No: 1431291-44-9

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  • 1431291-44-9 Structure

  • Basic information

    1. Product Name: Mal-amido-PEG2-TFP ester
    2. Synonyms: Mal-amido-PEG2-TFP ester;Mal-NH-PEG2-TFP
    3. CAS NO:1431291-44-9
    4. Molecular Formula: C20H20F4N2O7
    5. Molecular Weight: 476.3756128
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1431291-44-9.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: Soluble in DMSO, DCM, DMF
    9. CAS DataBase Reference: Mal-amido-PEG2-TFP ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: Mal-amido-PEG2-TFP ester(1431291-44-9)
    11. EPA Substance Registry System: Mal-amido-PEG2-TFP ester(1431291-44-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1431291-44-9(Hazardous Substances Data)

1431291-44-9 Usage

Uses

Used in Bioconjugation:
Mal-amido-PEG2-TFP ester is used as a bioconjugation agent for the selective attachment of thiol-containing biomolecules, such as proteins or peptides, due to the reactivity of its maleimide group with thiols. This selective attachment allows for the creation of stable and functional bioconjugates with minimal disruption to the native structure and function of the biomolecule.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Mal-amido-PEG2-TFP ester is used as a component in drug delivery systems to improve the solubility and bioavailability of hydrophobic drugs. The hydrophilic PEG chains enhance the water solubility of the drug, allowing for better dispersion and absorption in the body. Additionally, the maleimide and TFP ester end groups can be utilized for the covalent attachment of drugs to the PEG linker, providing a stable and controlled release platform.
Used in Diagnostics:
Mal-amido-PEG2-TFP ester can be employed in the development of diagnostic tools, such as imaging agents or sensors, by taking advantage of its reactivity with thiol-containing biomolecules. The maleimide group can be used to attach specific targeting moieties or contrast agents to the PEG linker, enabling the selective detection and imaging of biological processes or disease markers.
Used in Polymer Science:
In polymer science, Mal-amido-PEG2-TFP ester can be utilized as a building block for the synthesis of functional polymers with tailored properties. The maleimide and TFP ester end groups can be used to initiate or control the polymerization process, allowing for the creation of polymers with specific architectures, such as block copolymers or star polymers, for various applications in materials science and nanotechnology.

Check Digit Verification of cas no

The CAS Registry Mumber 1431291-44-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,3,1,2,9 and 1 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1431291-44:
(9*1)+(8*4)+(7*3)+(6*1)+(5*2)+(4*9)+(3*1)+(2*4)+(1*4)=129
129 % 10 = 9
So 1431291-44-9 is a valid CAS Registry Number.

1431291-44-9Upstream product

1431291-44-9Downstream Products

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