Intramolecular PdII-catalyzed dehydrogenative C(sp 3)-C(sp2) coupling: An alternative to Pd 0-catalyzed C(sp3)-H arylation from aryl halides?
The synthesis of fused thiophene-cyclopentanes by PdII-catalyzed dehydrogenative C(sp2)-H/C(sp3)-H coupling is described. This reaction shows interesting chemo- and diastereoselectivity, however a direct comparison showed that it is yet much less efficient than the two-step sequence composed of electrophilic halogenation and Pd0-catalyzed C(sp3)-H arylation.
Pierre, Cathleen,Baudoin, Olivier
p. 4473 - 4478
(2013/06/26)
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