143262-17-3

Basic information

• Product Name: 7-BROMO-2,3-DIHYDRO-INDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: BOC-7-BROMOINDOLINE;7-BROMO-2,3-DIHYDRO-INDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;N-Boc-7-bromoindoline;tert-butyl 7-bromoindoline-1-carboxylate;7-broMo-N-Boc-indoline;1H-Indole-1-carboxylicacid, 7-broMo-2,3-dihydro-, 1,1-diMethylethyl ester;1-Boc-7-bromoindoline
• CAS NO: 143262-17-3
• Molecular Formula: C13H16BrNO2
• Molecular Weight: 298.18
• Product Categories: Indoline & Oxindole
• Mol File: 143262-17-3.mol

Chemical Properties

• Boiling Point: 349.9 °C at 760 mmHg
• Flash Point: 165.4 °C
• Appearance: /
• Density: 1.4 g/cm³
• Vapor Pressure: 4.55E-05mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 7-BROMO-2,3-DIHYDRO-INDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 7-BROMO-2,3-DIHYDRO-INDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(143262-17-3)
• EPA Substance Registry System: 7-BROMO-2,3-DIHYDRO-INDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(143262-17-3)

Safety Data

• Hazardous Substances Data: 143262-17-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
7-BROMO-2,3-DIHYDRO-INDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is used as a research compound for its potential pharmacological properties. It is particularly valuable in the development of new drugs and therapies due to its enzyme inhibitory activity.
Used in Enzyme Inhibition Studies:
In the field of biochemistry, 7-BROMO-2,3-DIHYDRO-INDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is utilized as an enzyme inhibitor. Its ability to inhibit specific enzymes can be crucial in understanding enzyme functions and developing treatments for various diseases.
Used in Drug Development:
7-BROMO-2,3-DIHYDRO-INDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is employed in the pharmaceutical industry as a precursor or intermediate in the synthesis of new drugs. Its potential therapeutic applications make it a promising candidate for the development of innovative medications.
Used in Chemical Synthesis:
In the chemical industry, 7-BROMO-2,3-DIHYDRO-INDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is used as a building block in the synthesis of various organic compounds. Its unique structure and functional groups make it a versatile component in the creation of new chemical entities.

InChI:InChI=1/C13H16BrNO2/c1-13(2,3)17-12(16)15-8-7-9-5-4-6-10(14)11(9)15/h4-6H,7-8H2,1-3H3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 496-15-1 1-indoline 
• 143262-10-6 1-(tert-butoxycarbonyl)indoline 

Downstream Products

• 154077-55-1 2-(1-Benzyl-2,3-dihydro-1H-indol-7-yl)-4,5-dimethoxy-benzoic acid 2-amino-2-methyl-propyl ester 
• 154077-54-0 1-Benzyl-7-[2-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-4,5-dimethoxy-phenyl]-2,3-dihydro-1H-indole 
• 154077-56-2 2-(1-Benzyl-2,3-dihydro-1H-indol-7-yl)-4,5-dimethoxy-benzoic acid methyl ester 
• 63839-23-6 N-benzyl-7-bromoindoline 

Relevant articles and documents

A total synthesis of the pyrrolophenthridone alkaloid oxoassoanine

Coupling of the Grignard derived from N-Benzyl-7-bromoindoline with an aryl oxazoline leads to the title compound in good yield (Scheme 3). This methodology provides a versatile route to the Pyrrolophenthridone class of alkaloids.

DIRECTED LITHIATION OF 1-(tert-BUTOXYCARBONYL)INDOLINES. A CONVENIENT ROUTE TO 7-SUBSTITUTED INDOLINES

1-(tert-Butoxycarbonyl)indolines were regioselectively lithiated at 7-position with s-BuLi-TMEDA in ether or THF at -78 deg C.The lithiated species were reacted with a range of electrophiles to give 7-substituted indoline derivatives.