Quinine-catalysed double Michael addition of malononitrile to 1,5-disubstituted pentadien-3-ones: A stereoselective route to cyclohexanones
The stereoselective synthesis of 4-oxo-2,6-diaryl-cyclohexane-1,1- dicarbonitriles has been developed through double Michael addition of malononitrile to 1,5-disubstituted pentadien-3-ones catalysed by quinine. This simple cascade process affords cyclohex
De Fusco, Claudia,Lattanzi, Alessandra
supporting information; experimental part
p. 3728 - 3731
(2011/09/16)
Asymmetric organocatalytic double-conjugate addition of malononitrile to dienones: Efficient synthesis of optically active cyclohexanones
9-Amino-9-deoxyepiquinine efficiently catalyzed the double-conjugate addition of malononitrile to dienones. A number of 1,1,2,6-tetrasubstituted cyclohexanones were prepared in good yields, diastereoselectivities, and excellent enantioselectivities.
Li, Xue-Ming,Wang, Bo,Zhang, Jun-Min,Yan, Ming
supporting information; experimental part
p. 374 - 377
(2011/04/15)
On the Stereochemistry of Diaryl-Substituted Cyclohexanones Formed by Michael Reactions. Trans to Cis Isomerization of Their Ketals under Basic Conditions
The stereochemistry of C-1-substituted 2,6-diphenylcyclohexan-4-ones 1-3 prepared by Michael reactions has been investigated. While preparations of these compounds have been reported over the past 70 years, in many instances the correct stereochemistry at
Rowland, Alex T.,Filla, Sandra A.,Coutlangus, Marilyn L.,Winemiller, Mark D.,Chamberlin, Mark J.,Czulada, Gary,Johnson, Steven D.,Sabat, Michal
p. 4359 - 4365
(2007/10/03)
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